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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 1
1978 1
1981 1
1982 2
1983 1
1984 3
1985 2
1986 2
1987 7
1988 8
1989 14
1990 10
1991 17
1992 29
1993 33
1994 44
1995 25
1996 39
1997 53
1998 46
1999 55
2000 69
2001 65
2002 100
2003 129
2004 138
2005 193
2006 196
2007 222
2008 256
2009 294
2010 304
2011 393
2012 466
2013 574
2014 793
2015 944
2016 976
2017 1052
2018 1290
2019 1460
2020 1630
2021 1839
2022 2273
2023 2211
2024 941

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17,054 results

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Page 1
Targeting m(6)A binding protein YTHDFs for cancer therapy.
Zhang W, Wu T, Zhang Y, Kang W, Du C, You Q, Chen X, Jiang Z. Zhang W, et al. Among authors: jiang z. Bioorg Med Chem. 2023 Jul 15;90:117373. doi: 10.1016/j.bmc.2023.117373. Epub 2023 Jun 12. Bioorg Med Chem. 2023. PMID: 37329678 Review.
N(6)-methyladenosine (m(6)A) is the most common mRNA modification in mammalians. The function and dynamic regulation of m(6)A depends on the "writer", "readers" and "erasers". YT521-B homology domain family (YTHDF) is a class of m(6)A binding proteins, includ …
N(6)-methyladenosine (m(6)A) is the most common mRNA modification in mammalians. The function and dynamic regulation of m(6)A …
TROP2 translation mediated by dual m(6)A/m(7)G RNA modifications promotes bladder cancer development.
Chen C, Chao Y, Zhang C, Hu W, Huang Y, Lv Y, Liu B, Ji D, Liu M, Yang B, Jiang L, Liang Y, Zhang H, Yuan G, Ying X, Ji W. Chen C, et al. Among authors: jiang l. Cancer Lett. 2023 Jul 10;566:216246. doi: 10.1016/j.canlet.2023.216246. Epub 2023 Jun 1. Cancer Lett. 2023. PMID: 37268280
RNA modifications, including adenine methylation (m(6)A) of mRNA and guanine methylation (m(7)G) of tRNA, are crucial for the biological function of RNA. ...We demonstrated that m(6)A methyltransferase METTL3-mediated programmable m(6)A modification of …
RNA modifications, including adenine methylation (m(6)A) of mRNA and guanine methylation (m(7)G) of tRNA, are crucial for the …
RNA N6-methyladenosine in nonocular and ocular disease.
Wang N, Yao F, Liu D, Jiang H, Xia X, Xiong S. Wang N, et al. Among authors: jiang h. J Cell Physiol. 2022 Mar;237(3):1686-1710. doi: 10.1002/jcp.30652. Epub 2021 Dec 15. J Cell Physiol. 2022. PMID: 34913163 Review.
N(6) -methyladenosine (m(6) A), the sixth N methylation of adenylate (A) in RNA, is the most abundant transcriptome modification in eukaryotic messenger RNA (mRNAs). m(6) A modification exists in both coding mRNA and noncoding RNAs, and its functions are controlled …
N(6) -methyladenosine (m(6) A), the sixth N methylation of adenylate (A) in RNA, is the most abundant transcriptome modification in e …
RNA Modification by m(6)A Methylation in Cardiovascular Disease.
Chen J, Wei X, Yi X, Jiang DS. Chen J, et al. Among authors: jiang ds. Oxid Med Cell Longev. 2021 Feb 9;2021:8813909. doi: 10.1155/2021/8813909. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 34221238 Free PMC article. Review.
After the initial identification of m(6)A RNA methylation in 1974, the rise of next-generation sequencing technology to detect m(6)A throughout the transcriptome led to its renewed recognition in 2012. ...Finally, we discuss future directions for m(6)A methyl …
After the initial identification of m(6)A RNA methylation in 1974, the rise of next-generation sequencing technology to detect m …
Downregulated FTO Promotes MicroRNA-155-mediated Inflammatory Response in Cerebral Ischemia/Reperfusion Injury.
Jiang Z, Shi L, Huang H, Lei D, Lou L, Jin Y, Sun J, Wang L. Jiang Z, et al. Neuroscience. 2023 Aug 21;526:305-313. doi: 10.1016/j.neuroscience.2023.07.012. Epub 2023 Jul 11. Neuroscience. 2023. PMID: 37437797
Finally, the role of miR-155 overexpression in the protective effects of FTO on cerebral I/R injury was examined. m(6)A levels of total RNA were increased, and m(6)A methyltransferase FTO expression was decreased in post-I/R injury cerebral tissues. FTO overexpressi …
Finally, the role of miR-155 overexpression in the protective effects of FTO on cerebral I/R injury was examined. m(6)A levels of tot …
The Role of RNA m(6)A Modification in Cancer Glycolytic Reprogramming.
Li Y, Huang H, Wu S, Zhou Y, Huang T, Jiang J. Li Y, et al. Among authors: jiang j. Curr Gene Ther. 2023;23(1):51-59. doi: 10.2174/1566523222666220830150446. Curr Gene Ther. 2023. PMID: 36043793 Review.
The aberration of m(6)A modification can be observed in a variety of diseases such as diabetes, neurological diseases and cancers. This review describes the mechanisms of m(6)A on cancer glycolysis and their applications in cancer therapy and prognosis evaluation, a …
The aberration of m(6)A modification can be observed in a variety of diseases such as diabetes, neurological diseases and cancers. Th …
Modified Biejia Jianwan decoction restrains PD-L1-mediated immune evasion through the HIF-1α/STAT3/NF-κB signaling pathway.
Tian X, Liu F, Wang Z, Zhang J, Liu Q, Zhang Y, Zhang D, Huang C, Zhao J, Jiang S. Tian X, et al. Among authors: jiang s. J Ethnopharmacol. 2024 Mar 25;322:117577. doi: 10.1016/j.jep.2023.117577. Epub 2023 Dec 15. J Ethnopharmacol. 2024. PMID: 38104877 Free article.
Additionally, we assessed M-BJJW's impact on hypoxia-induced alterations in HCC cell lines using immunofluorescence and Western blot assessments. ...The CCK-8 assay and co-culture techniques demonstrated the anti-tumor activity of M-BJJW. Immunofluorescence and west …
Additionally, we assessed M-BJJW's impact on hypoxia-induced alterations in HCC cell lines using immunofluorescence and Western blot …
Evaluation of the Inhibition Potency of Nirmatrelvir against Main Protease Mutants of SARS-CoV-2 Variants.
Jiang H, Zhou Y, Zou X, Hu X, Wang J, Zeng P, Li W, Zeng X, Zhang J, Li J. Jiang H, et al. Biochemistry. 2023 Jul 4;62(13):2055-2064. doi: 10.1021/acs.biochem.3c00075. Epub 2023 May 24. Biochemistry. 2023. PMID: 37222536
We evaluated the inhibition potency of nirmatrelvir against these M(pro) mutants and solved the crystal structures of representative M(pro) mutants of SARS-CoV-2 bound to nirmatrelvir. Enzymatic inhibition assays revealed that these M(pro) variants remain sus …
We evaluated the inhibition potency of nirmatrelvir against these M(pro) mutants and solved the crystal structures of representative …
Crystal structures of main protease (M(pro)) mutants of SARS-CoV-2 variants bound to PF-07304814.
Jiang H, Zou X, Zeng P, Zeng X, Zhou X, Wang J, Zhang J, Li J. Jiang H, et al. Mol Biomed. 2023 Aug 3;4(1):23. doi: 10.1186/s43556-023-00134-2. Mol Biomed. 2023. PMID: 37532968 Free PMC article.
We previously solved the structure of PF-07304814 in complex with SARS-CoV-2 M(pro). However, the binding modes of PF-07304814 with M(pro)s from evolving SARS-CoV-2 variants is under-determined. ...Structural analysis provided insight into the key molecular determin …
We previously solved the structure of PF-07304814 in complex with SARS-CoV-2 M(pro). However, the binding modes of PF-07304814 with …
The Mechanism and Role of N(6)-Methyladenosine (m(6)A) Modification in Atherosclerosis and Atherosclerotic Diseases.
Tan Q, He S, Leng X, Zheng D, Mao F, Hao J, Chen K, Jiang H, Lin Y, Yang J. Tan Q, et al. Among authors: jiang h. J Cardiovasc Dev Dis. 2022 Oct 25;9(11):367. doi: 10.3390/jcdd9110367. J Cardiovasc Dev Dis. 2022. PMID: 36354766 Free PMC article. Review.
N(6)-methyladenosine (m(6)A) modification is a newly discovered regulatory mechanism in eukaryotes. ...Subsequently, we illustrate the m(6)A-mediated aberrant biological role in the pathogenesis of AS and AD, and analyze the levels of m(6)A methylation in per …
N(6)-methyladenosine (m(6)A) modification is a newly discovered regulatory mechanism in eukaryotes. ...Subsequently, we illustrate th …
17,054 results
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