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Neoadjuvant Nivolumab Plus Ipilimumab and Adjuvant Nivolumab in Localized Deficient Mismatch Repair/Microsatellite Instability-High Gastric or Esophagogastric Junction Adenocarcinoma: The GERCOR NEONIPIGA Phase II Study.
André T, Tougeron D, Piessen G, de la Fouchardière C, Louvet C, Adenis A, Jary M, Tournigand C, Aparicio T, Desrame J, Lièvre A, Garcia-Larnicol ML, Pudlarz T, Cohen R, Memmi S, Vernerey D, Henriques J, Lefevre JH, Svrcek M. André T, et al. Among authors: svrcek m. J Clin Oncol. 2023 Jan 10;41(2):255-265. doi: 10.1200/JCO.22.00686. Epub 2022 Aug 15. J Clin Oncol. 2023. PMID: 35969830 Free PMC article. Clinical Trial.
PATIENTS AND METHODS: NEONIPIGA (ClinicalTrials.gov identifier: NCT04006262) phase II study evaluated neoadjuvant nivolumab 240 mg once every two weeks 6 and ipilimumab 1 mg/kg once every six weeks 2, followed by surgery and adjuvant nivolumab 480 mg once every four weeks (nine i …
PATIENTS AND METHODS: NEONIPIGA (ClinicalTrials.gov identifier: NCT04006262) phase II study evaluated neoadjuvant nivolumab 240 mg once ever …
Pacpaint: a histology-based deep learning model uncovers the extensive intratumor molecular heterogeneity of pancreatic adenocarcinoma.
Saillard C, Delecourt F, Schmauch B, Moindrot O, Svrcek M, Bardier-Dupas A, Emile JF, Ayadi M, Rebours V, de Mestier L, Hammel P, Neuzillet C, Bachet JB, Iovanna J, Dusetti N, Blum Y, Richard M, Kermezli Y, Paradis V, Zaslavskiy M, Courtiol P, Kamoun A, Nicolle R, Cros J. Saillard C, et al. Among authors: svrcek m. Nat Commun. 2023 Jun 13;14(1):3459. doi: 10.1038/s41467-023-39026-y. Nat Commun. 2023. PMID: 37311751 Free PMC article.
PACpAInt is trained on a multicentric cohort (n = 202) and validated on 4 independent cohorts including biopsies (surgical cohorts n = 148; 97; 126 / biopsy cohort n = 25), all with transcriptomic data (n = 598) to predict tumor tissue, tumor cells from stroma, and their transcri …
PACpAInt is trained on a multicentric cohort (n = 202) and validated on 4 independent cohorts including biopsies (surgical cohorts n = 148; …
Validation of MSIntuit as an AI-based pre-screening tool for MSI detection from colorectal cancer histology slides.
Saillard C, Dubois R, Tchita O, Loiseau N, Garcia T, Adriansen A, Carpentier S, Reyre J, Enea D, von Loga K, Kamoun A, Rossat S, Wiscart C, Sefta M, Auffret M, Guillou L, Fouillet A, Kather JN, Svrcek M. Saillard C, et al. Among authors: svrcek m. Nat Commun. 2023 Nov 6;14(1):6695. doi: 10.1038/s41467-023-42453-6. Nat Commun. 2023. PMID: 37932267 Free PMC article.
Oxaliplatin, 5-Fluorouracil and Nab-paclitaxel as perioperative regimen in patients with resectable gastric adenocarcinoma: A GERCOR phase II study (FOXAGAST).
Watson S, de la Fouchardière C, Kim S, Cohen R, Bachet JB, Tournigand C, Ferraz JM, Lefevre M, Colin D, Svrcek M, Meurisse A, Louvet C. Watson S, et al. Among authors: svrcek m. Eur J Cancer. 2019 Jan;107:46-52. doi: 10.1016/j.ejca.2018.11.006. Epub 2018 Dec 7. Eur J Cancer. 2019. PMID: 30529902 Clinical Trial.
RGA patients were assigned to receive neoadjuvant Nab-paclitaxel (150 mg/m(2)) and FOLFOX q2w for six cycles. Six additional post-operative cycles were kept at the investigator's discretion. ...
RGA patients were assigned to receive neoadjuvant Nab-paclitaxel (150 mg/m(2)) and FOLFOX q2w for six cycles. Six additional post-ope …
Energy band diagram of device-grade silicon nanocrystals.
Macias-Montero M, Askari S, Mitra S, Rocks C, Ni C, Svrcek V, Connor PA, Maguire P, Irvine JT, Mariotti D. Macias-Montero M, et al. Among authors: svrcek v. Nanoscale. 2016 Mar 28;8(12):6623-8. doi: 10.1039/c5nr07705b. Nanoscale. 2016. PMID: 26939617 Free article.