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Did you mean m zajc[Author] (22 results)?
Mass Spectrometry for Identification, Monitoring, and Minimal Residual Disease Detection of M-Proteins.
Zajec M, Langerhorst P, VanDuijn MM, Gloerich J, Russcher H, van Gool AJ, Luider TM, Joosten I, de Rijke YB, Jacobs JFM. Zajec M, et al. Clin Chem. 2020 Mar 1;66(3):421-433. doi: 10.1093/clinchem/hvz041. Clin Chem. 2020. PMID: 32031591 Review.
BACKGROUND: Monoclonal gammopathies (MGs) are plasma cell disorders defined by the clonal expansion of plasma cells, resulting in the characteristic excretion of a monoclonal immunoglobulin (M-protein). M-protein detection and quantification are integral parts of th …
BACKGROUND: Monoclonal gammopathies (MGs) are plasma cell disorders defined by the clonal expansion of plasma cells, resulting in the charac …
Cryo-Gel embedding compound for renal biopsy biobanking.
Snijders MLH, Zajec M, Walter LAJ, de Louw RMAA, Oomen MHA, Arshad S, van den Bosch TPP, Dekker LJM, Doukas M, Luider TM, Riegman PHJ, van Kemenade FJ, Clahsen-van Groningen MC. Snijders MLH, et al. Among authors: zajec m. Sci Rep. 2019 Oct 24;9(1):15250. doi: 10.1038/s41598-019-51962-8. Sci Rep. 2019. PMID: 31649317 Free PMC article.
Monitoring the M-protein of multiple myeloma patients treated with a combination of monoclonal antibodies: the laboratory solution to eliminate interference.
Noori S, Verkleij CPM, Zajec M, Langerhorst P, Bosman PWC, de Rijke YB, Zweegman S, VanDuijn M, Luider T, van de Donk NWCJ, Jacobs JFM. Noori S, et al. Among authors: zajec m. Clin Chem Lab Med. 2021 Aug 16;59(12):1963-1971. doi: 10.1515/cclm-2021-0399. Print 2021 Nov 25. Clin Chem Lab Med. 2021. PMID: 34392637 Free article.
In all three patients the MS-MRD assay was also able to distinguish the M-protein from the t-mAbs. Additional advantage of the MS-MRD assay is that this multiplex assay is more sensitive and allows quantitative M-protein-, daratumumab- and nivolumab-monitoring. CONC …
In all three patients the MS-MRD assay was also able to distinguish the M-protein from the t-mAbs. Additional advantage of the MS-MRD …
Integrating Serum Protein Electrophoresis with Mass Spectrometry, A New Workflow for M-Protein Detection and Quantification.
Zajec M, Jacobs JFM, de Kat Angelino CM, Dekker LJM, Stingl C, Luider TM, De Rijke YB, VanDuijn MM. Zajec M, et al. J Proteome Res. 2020 Jul 2;19(7):2845-2853. doi: 10.1021/acs.jproteome.9b00705. Epub 2020 Jan 14. J Proteome Res. 2020. PMID: 31895568
Using TMT labeling, M-protein can be compared in different samples from the same patient. We have successfully measured M-protein proteotypic peptides extracted from the SPE/IFE gels utilizing SIL peptides and TMT....
Using TMT labeling, M-protein can be compared in different samples from the same patient. We have successfully measured M-prot …
Optimisation of pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives as novel Hsp90 C-terminal domain inhibitors against Ewing sarcoma.
Zajec Ž, Dernovšek J, Distel M, Gobec M, Tomašič T. Zajec Ž, et al. Bioorg Chem. 2023 Feb;131:106311. doi: 10.1016/j.bioorg.2022.106311. Epub 2022 Dec 5. Bioorg Chem. 2023. PMID: 36495678 Free article.
In this article, we report a new structural class of allosteric Hsp90 C-terminal domain (CTD) inhibitors based on the virtual screening hit TVS24, which showed antiproliferative activity in the SK-N-MC Ewing sarcoma cell line with an IC(50) value of 15.9 0.7 M. The optimis …
In this article, we report a new structural class of allosteric Hsp90 C-terminal domain (CTD) inhibitors based on the virtual screening hit …
Development of a Targeted Mass-Spectrometry Serum Assay To Quantify M-Protein in the Presence of Therapeutic Monoclonal Antibodies.
Zajec M, Jacobs JFM, Groenen PJTA, de Kat Angelino CM, Stingl C, Luider TM, De Rijke YB, VanDuijn MM. Zajec M, et al. J Proteome Res. 2018 Mar 2;17(3):1326-1333. doi: 10.1021/acs.jproteome.7b00890. Epub 2018 Feb 15. J Proteome Res. 2018. PMID: 29424538
M-protein diagnostics can be compromised for patients receiving therapeutic monoclonal antibodies as treatment in multiple myeloma. ...We address the sensitivity in M-protein diagnostics and show that our mass-spectrometry assay is more than two orders of magnitude …
M-protein diagnostics can be compromised for patients receiving therapeutic monoclonal antibodies as treatment in multiple myeloma. . …
In Silico Discovery and Optimisation of a Novel Structural Class of Hsp90 C-Terminal Domain Inhibitors.
Zajec Ž, Dernovšek J, Gobec M, Tomašič T. Zajec Ž, et al. Biomolecules. 2022 Jun 24;12(7):884. doi: 10.3390/biom12070884. Biomolecules. 2022. PMID: 35883440 Free PMC article.
Three selected virtual hits were tested in the MCF-7 breast cancer cell line, with compound TVS-23 showing antiproliferative activity with an IC(50) value of 26.4 1.1 M. We report here the optimisation, synthesis and biological evaluation of TVS-23 analogues. Several analo …
Three selected virtual hits were tested in the MCF-7 breast cancer cell line, with compound TVS-23 showing antiproliferative activity with a …
Multiple Myeloma Minimal Residual Disease Detection: Targeted Mass Spectrometry in Blood vs Next-Generation Sequencing in Bone Marrow.
Langerhorst P, Noori S, Zajec M, De Rijke YB, Gloerich J, van Gool AJ, Caillon H, Joosten I, Luider TM, Corre J, VanDuijn MM, Dejoie T, Jacobs JFM. Langerhorst P, et al. Among authors: zajec m. Clin Chem. 2021 Nov 26;67(12):1689-1698. doi: 10.1093/clinchem/hvab187. Clin Chem. 2021. PMID: 34643690 Clinical Trial.
RESULTS: In all 41 patients we were able to identify clonotypic M-protein-specific peptides and perform serum-based MS-MRD measurements. MS-MRD is significantly more sensitive to detect M-protein compared to either electrophoretic M-protein diagnostics or ser …
RESULTS: In all 41 patients we were able to identify clonotypic M-protein-specific peptides and perform serum-based MS-MRD measuremen …
Multi-Omics Profiling in Marfan Syndrome: Further Insights into the Molecular Mechanisms Involved in Aortic Disease.
Verhagen JMA, Burger J, Bekkers JA, den Dekker AT, von der Thüsen JH, Zajec M, Brüggenwirth HT, van der Sterre MLT, van den Born M, Luider TM, van IJcken WFJ, Wessels MW, Essers J, Roos-Hesselink JW, van der Pluijm I, van de Laar IMBH, Brosens E. Verhagen JMA, et al. Among authors: zajec m. Int J Mol Sci. 2021 Dec 31;23(1):438. doi: 10.3390/ijms23010438. Int J Mol Sci. 2021. PMID: 35008861 Free PMC article.