Märki HP - Search Results

1

A novel partial agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) recruits PPARgamma-coactivator-1alpha, prevents triglyceride accumulation, and potentiates insulin signaling in vitro.

Burgermeister E, Schnoebelen A, Flament A, Benz J, Stihle M, Gsell B, Rufer A, Ruf A, Kuhn B, Märki HP, Mizrahi J, Sebokova E, Niesor E, Meyer M. Burgermeister E, et al. Among authors: marki hp. Mol Endocrinol. 2006 Apr;20(4):809-30. doi: 10.1210/me.2005-0171. Epub 2005 Dec 22. Mol Endocrinol. 2006. PMID: 16373399

2

Structure-based design of indole propionic acids as novel PPARalpha/gamma co-agonists.

Kuhn B, Hilpert H, Benz J, Binggeli A, Grether U, Humm R, Märki HP, Meyer M, Mohr P. Kuhn B, et al. Among authors: marki hp. Bioorg Med Chem Lett. 2006 Aug 1;16(15):4016-20. doi: 10.1016/j.bmcl.2006.05.007. Epub 2006 Jun 5. Bioorg Med Chem Lett. 2006. PMID: 16737814

3

Design and biological evaluation of novel, balanced dual PPARalpha/gamma agonists.

Grether U, Bénardeau A, Benz J, Binggeli A, Blum D, Hilpert H, Kuhn B, Märki HP, Meyer M, Mohr P, Püntener K, Raab S, Ruf A, Schlatter D. Grether U, et al. Among authors: marki hp. ChemMedChem. 2009 Jun;4(6):951-6. doi: 10.1002/cmdc.200800425. ChemMedChem. 2009. PMID: 19326383

4

Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes.

Bénardeau A, Benz J, Binggeli A, Blum D, Boehringer M, Grether U, Hilpert H, Kuhn B, Märki HP, Meyer M, Püntener K, Raab S, Ruf A, Schlatter D, Mohr P. Bénardeau A, et al. Among authors: marki hp. Bioorg Med Chem Lett. 2009 May 1;19(9):2468-73. doi: 10.1016/j.bmcl.2009.03.036. Epub 2009 Mar 14. Bioorg Med Chem Lett. 2009. PMID: 19349176

5

Challenges and Rewards in Medicinal Chemistry Targeting Cardiovascular and Metabolic Diseases.

Neidhart W, Ackermann J, Amrein K, Conte A, Hunziker D, Kuhn B, Märki HP, Nettekoven M, Ruf A, Schulz-Gasch T, Mayweg AV. Neidhart W, et al. Among authors: marki hp. Chimia (Aarau). 2015;69(7-8):407-13. doi: 10.2533/chimia.2015.407. Chimia (Aarau). 2015. PMID: 26507592 Free article. Review.

6

Challenges and Rewards in Medicinal Chemistry Targeting Cardiovascular and Metabolic Diseases.

Neidhart W, Ackermann J, Amrein K, Conte A, Hunziker D, Kuhn B, Märki HP, Nettekoven M, Ruf A, Schulz-Gasch T, Mayweg AV. Neidhart W, et al. Among authors: marki hp. Chimia (Aarau). 2015 Aug 19;69(7):407-413. doi: 10.2533/chimia.2015.407. Chimia (Aarau). 2015. PMID: 28482972 Free article.

7

Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2).

Martin RE, Lehmann J, Alzieu T, Lenz M, Carnero Corrales MA, Aebi JD, Märki HP, Kuhn B, Amrein K, Mayweg AV, Britton R. Martin RE, et al. Among authors: marki hp. Org Biomol Chem. 2016 Jul 7;14(25):5922-7. doi: 10.1039/c6ob00848h. Epub 2016 Jun 1. Org Biomol Chem. 2016. PMID: 27245438

8

Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys.

Martin RE, Aebi JD, Hornsperger B, Krebs HJ, Kuhn B, Kuglstatter A, Alker AM, Märki HP, Müller S, Burger D, Ottaviani G, Riboulet W, Verry P, Tan X, Amrein K, Mayweg AV. Martin RE, et al. Among authors: marki hp. J Med Chem. 2015 Oct 22;58(20):8054-65. doi: 10.1021/acs.jmedchem.5b00851. Epub 2015 Oct 2. J Med Chem. 2015. PMID: 26403853

9

Substituted piperidines--highly potent renin inhibitors due to induced fit adaptation of the active site.

Vieira E, Binggeli A, Breu V, Bur D, Fischli W, Güller R, Hirth G, Märki HP, Müller M, Oefner C, Scalone M, Stadler H, Wilhelm M, Wostl W. Vieira E, et al. Among authors: marki hp. Bioorg Med Chem Lett. 1999 May 17;9(10):1397-402. doi: 10.1016/s0960-894x(99)00195-x. Bioorg Med Chem Lett. 1999. PMID: 10360744

10

Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors.

Liu Y, Wu J, Zhou M, Chen W, Li D, Wang Z, Hornsperger B, Aebi JD, Märki HP, Kuhn B, Wang L, Kuglstatter A, Benz J, Müller S, Hochstrasser R, Ottaviani G, Xin J, Kirchner S, Mohr S, Verry P, Riboulet W, Shen HC, Mayweg AV, Amrein K, Tan X. Liu Y, et al. Among authors: marki hp. J Med Chem. 2020 Jul 9;63(13):6876-6897. doi: 10.1021/acs.jmedchem.0c00233. Epub 2020 Jun 25. J Med Chem. 2020. PMID: 32530624

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