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The C-terminal part of VIP is important for receptor binding and activation, as evidenced by chimeric constructs of VIP/secretin.
FEBS Lett. 1997 Aug 25;413(3):405-8. doi: 10.1016/s0014-5793(97)00942-3.
FEBS Lett. 1997.
PMID: 9303545
Free article.
Transmembrane α-helix 2 and 7 are important for small molecule-mediated activation of the GLP-1 receptor.
Rye Underwood C, Møller Knudsen S, Schjellerup Wulff B, Bräuner-Osborne H, Lau J, Knudsen LB, Peters GH, Reedtz-Runge S.
Rye Underwood C, et al. Among authors: moller knudsen s.
Pharmacology. 2011;88(5-6):340-8. doi: 10.1159/000334338. Epub 2011 Nov 30.
Pharmacology. 2011.
PMID: 22134089
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