Macdonald TL - Search Results

1

Reactivity of atropaldehyde, a felbamate metabolite in human liver tissue in vitro.

Kapetanovic IM, Torchin CD, Strong JM, Yonekawa WD, Lu C, Li AP, Dieckhaus CM, Santos WL, Macdonald TL, Sofia RD, Kupferberg HJ. Kapetanovic IM, et al. Among authors: macdonald tl. Chem Biol Interact. 2002 Nov 10;142(1-2):119-34. doi: 10.1016/s0009-2797(02)00058-3. Chem Biol Interact. 2002. PMID: 12399159

2

Mechanisms of idiosyncratic drug reactions: the case of felbamate.

Dieckhaus CM, Thompson CD, Roller SG, Macdonald TL. Dieckhaus CM, et al. Among authors: macdonald tl. Chem Biol Interact. 2002 Nov 10;142(1-2):99-117. doi: 10.1016/s0009-2797(02)00057-1. Chem Biol Interact. 2002. PMID: 12399158 Review.

3

Potentially reactive cyclic carbamate metabolite of the antiepileptic drug felbamate produced by human liver tissue in vitro.

Kapetanovic IM, Torchin CD, Thompson CD, Miller TA, McNeilly PJ, Macdonald TL, Kupferberg HJ, Perhach JL, Sofia RD, Strong JM. Kapetanovic IM, et al. Among authors: macdonald tl. Drug Metab Dispos. 1998 Nov;26(11):1089-95. Drug Metab Dispos. 1998. PMID: 9806951

4

Interaction between human serum albumin and the felbamate metabolites 4-Hydroxy-5-phenyl-[1,3]oxazinan-2-one and 2-phenylpropenal.

Roller SG, Dieckhaus CM, Santos WL, Sofia RD, Macdonald TL. Roller SG, et al. Among authors: macdonald tl. Chem Res Toxicol. 2002 Jun;15(6):815-24. doi: 10.1021/tx025509h. Chem Res Toxicol. 2002. PMID: 12067249

5

The synthesis, in vitro reactivity, and evidence for formation in humans of 5-phenyl-1,3-oxazinane-2,4-dione, a metabolite of felbamate.

Thompson CD, Miller TA, Barthen MT, Dieckhaus CM, Sofia RD, Macdonald TL. Thompson CD, et al. Among authors: macdonald tl. Drug Metab Dispos. 2000 Apr;28(4):434-9. Drug Metab Dispos. 2000. PMID: 10725312 Clinical Trial.

6

A mechanistic approach to understanding species differences in felbamate bioactivation: relevance to drug-induced idiosyncratic reactions.

Dieckhaus CM, Miller TA, Sofia RD, Macdonald TL. Dieckhaus CM, et al. Among authors: macdonald tl. Drug Metab Dispos. 2000 Jul;28(7):814-22. Drug Metab Dispos. 2000. PMID: 10859156

7

Role of glutathione S-transferases A1-1, M1-1, and P1-1 in the detoxification of 2-phenylpropenal, a reactive felbamate metabolite.

Dieckhaus CM, Roller SG, Santos WL, Sofia RD, Macdonald TL. Dieckhaus CM, et al. Among authors: macdonald tl. Chem Res Toxicol. 2001 May;14(5):511-6. doi: 10.1021/tx000141e. Chem Res Toxicol. 2001. PMID: 11368548

8

The chemistry, toxicology, and identification in rat and human urine of 4-hydroxy-5-phenyl-1,3-oxazaperhydroin-2-one: a reactive metabolite in felbamate bioactivation.

Dieckhaus CM, Santos WL, Sofia RD, Macdonald TL. Dieckhaus CM, et al. Among authors: macdonald tl. Chem Res Toxicol. 2001 Aug;14(8):958-64. doi: 10.1021/tx000139n. Chem Res Toxicol. 2001. PMID: 11511169

9

Quantification in patient urine samples of felbamate and three metabolites: acid carbamate and two mercapturic acids.

Thompson CD, Barthen MT, Hopper DW, Miller TA, Quigg M, Hudspeth C, Montouris G, Marsh L, Perhach JL, Sofia RD, Macdonald TL. Thompson CD, et al. Among authors: macdonald tl. Epilepsia. 1999 Jun;40(6):769-76. doi: 10.1111/j.1528-1157.1999.tb00777.x. Epilepsia. 1999. PMID: 10368077 Free article.

10

Lysophosphatidic acid-induced mitogenesis is regulated by lipid phosphate phosphatases and is Edg-receptor independent.

Hooks SB, Santos WL, Im DS, Heise CE, Macdonald TL, Lynch KR. Hooks SB, et al. Among authors: macdonald tl. J Biol Chem. 2001 Feb 16;276(7):4611-21. doi: 10.1074/jbc.M007782200. Epub 2000 Oct 19. J Biol Chem. 2001. PMID: 11042183 Free article.

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