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Revisiting the role of dihydroorotate dehydrogenase as a therapeutic target for cancer.
Pharmacol Ther. 2019 Mar;195:111-131. doi: 10.1016/j.pharmthera.2018.10.012. Epub 2018 Oct 19.
Pharmacol Ther. 2019.
PMID: 30347213
Review.
Membrane permeable lipophilic cations as mitochondrial directing groups.
Madak JT, Neamati N.
Madak JT, et al.
Curr Top Med Chem. 2015;15(8):745-66. doi: 10.2174/1568026615666150302105622.
Curr Top Med Chem. 2015.
PMID: 25732791
Review.
Item in Clipboard
The Dihydroorotate Dehydrogenase Inhibitor Brequinar Is Synergistic with ENT1/2 Inhibitors.
Cuthbertson CR, Guo H, Kyani A, Madak JT, Arabzada Z, Neamati N.
Cuthbertson CR, et al. Among authors: madak jt.
ACS Pharmacol Transl Sci. 2020 Nov 23;3(6):1242-1252. doi: 10.1021/acsptsci.0c00124. eCollection 2020 Dec 11.
ACS Pharmacol Transl Sci. 2020.
PMID: 33344900
Free PMC article.
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Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase.
Madak JT, Cuthbertson CR, Miyata Y, Tamura S, Petrunak EM, Stuckey JA, Han Y, He M, Sun D, Showalter HD, Neamati N.
Madak JT, et al.
J Med Chem. 2018 Jun 28;61(12):5162-5186. doi: 10.1021/acs.jmedchem.7b01862. Epub 2018 May 14.
J Med Chem. 2018.
PMID: 29727569
Free PMC article.
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Design, Synthesis, and Characterization of Brequinar Conjugates as Probes to Study DHODH Inhibition.
Madak JT, Cuthbertson CR, Chen W, Showalter HD, Neamati N.
Madak JT, et al.
Chemistry. 2017 Oct 9;23(56):13875-13878. doi: 10.1002/chem.201702999. Epub 2017 Sep 12.
Chemistry. 2017.
PMID: 28833638
Free article.
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