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Multiple molecular mechanisms are involved in the activation of the kidney sodium-chloride cotransporter by hypokalemia.
Murillo-de-Ozores AR, Carbajal-Contreras H, Magaña-Ávila GR, Valdés R, Grajeda-Medina LI, Vázquez N, Zariñán T, López-Saavedra A, Sharma A, Lin DH, Wang WH, Delpire E, Ellison DH, Gamba G, Castañeda-Bueno M. Murillo-de-Ozores AR, et al. Among authors: magana avila gr. Kidney Int. 2022 Nov;102(5):1030-1041. doi: 10.1016/j.kint.2022.06.027. Epub 2022 Jul 21. Kidney Int. 2022. PMID: 35870644 Free PMC article.
Arginine vasopressin regulates the renal Na+-Cl- and Na+-K+-Cl- cotransporters through with-no-lysine kinase 4 and inhibitor 1 phosphorylation.
Carbajal-Contreras H, Murillo-de-Ozores AR, Magaña-Avila G, Marquez-Salinas A, Bourqui L, Tellez-Sutterlin M, Bahena-Lopez JP, Cortes-Arroyo E, Behn-Eschenburg SG, Lopez-Saavedra A, Vazquez N, Ellison DH, Loffing J, Gamba G, Castañeda-Bueno M. Carbajal-Contreras H, et al. Among authors: magana avila g. Am J Physiol Renal Physiol. 2024 Feb 1;326(2):F285-F299. doi: 10.1152/ajprenal.00343.2023. Epub 2023 Dec 14. Am J Physiol Renal Physiol. 2024. PMID: 38096266
SIRT7 modulates the stability and activity of the renal K-Cl cotransporter KCC4 through deacetylation.
Noriega LG, Melo Z, Rajaram RD, Mercado A, Tovar AR, Velazquez-Villegas LA, Castañeda-Bueno M, Reyes-López Y, Ryu D, Rojas-Vega L, Magaña-Avila G, López-Barradas AM, Sánchez-Hernández M, Debonneville A, Doucet A, Cheval L, Torres N, Auwerx J, Staub O, Gamba G. Noriega LG, et al. Among authors: magana avila g. EMBO Rep. 2021 May 5;22(5):e50766. doi: 10.15252/embr.202050766. Epub 2021 Mar 22. EMBO Rep. 2021. PMID: 33749979 Free PMC article.