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Discovery of novel Hsp90 C-terminal domain inhibitors that disrupt co-chaperone binding.
Bioorg Med Chem Lett. 2021 Apr 15;38:127857. doi: 10.1016/j.bmcl.2021.127857. Epub 2021 Feb 18.
Bioorg Med Chem Lett. 2021.
PMID: 33609661
Identification of Isoform-Selective Ligands for the Middle Domain of Heat Shock Protein 90 (Hsp90).
Mak OW, Chand R, Reynisson J, Leung IKH.
Mak OW, et al.
Int J Mol Sci. 2019 Oct 26;20(21):5333. doi: 10.3390/ijms20215333.
Int J Mol Sci. 2019.
PMID: 31717777
Free PMC article.
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Discovery and Characterization of a Cryptic Secondary Binding Site in the Molecular Chaperone HSP70.
O'Connor S, Le Bihan YV, Westwood IM, Liu M, Mak OW, Zazeri G, Povinelli APR, Jones AM, van Montfort R, Reynisson J, Collins I.
O'Connor S, et al. Among authors: mak ow.
Molecules. 2022 Jan 26;27(3):817. doi: 10.3390/molecules27030817.
Molecules. 2022.
PMID: 35164081
Free PMC article.
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Chemical modulation of cytosolic BAX homodimer potentiates BAX activation and apoptosis.
Gitego N, Agianian B, Mak OW, Kumar Mv V, Cheng EH, Gavathiotis E.
Gitego N, et al. Among authors: mak ow.
Nat Commun. 2023 Dec 16;14(1):8381. doi: 10.1038/s41467-023-44084-3.
Nat Commun. 2023.
PMID: 38104127
Free PMC article.
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