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R1441G but not G2019S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils.
Fan Y, Nirujogi RS, Garrido A, Ruiz-Martínez J, Bergareche-Yarza A, Mondragón-Rezola E, Vinagre-Aragón A, Croitoru I, Gorostidi Pagola A, Paternain Markinez L, Alcalay R, Hickman RA, Düring J, Gomes S, Pratuseviciute N, Padmanabhan S, Valldeoriola F, Pérez Sisqués L, Malagelada C, Ximelis T, Molina Porcel L, Martí MJ, Tolosa E, Alessi DR, Sammler EM. Fan Y, et al. Among authors: malagelada c. Acta Neuropathol. 2021 Sep;142(3):475-494. doi: 10.1007/s00401-021-02325-z. Epub 2021 Jun 14. Acta Neuropathol. 2021. PMID: 34125248 Free PMC article.
Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson's disease.
Romaní-Aumedes J, Canal M, Martín-Flores N, Sun X, Pérez-Fernández V, Wewering S, Fernández-Santiago R, Ezquerra M, Pont-Sunyer C, Lafuente A, Alberch J, Luebbert H, Tolosa E, Levy OA, Greene LA, Malagelada C. Romaní-Aumedes J, et al. Among authors: malagelada c. Cell Death Dis. 2014 Aug 7;5(8):e1364. doi: 10.1038/cddis.2014.333. Cell Death Dis. 2014. PMID: 25101677 Free PMC article.
Synaptic RTP801 contributes to motor-learning dysfunction in Huntington's disease.
Martín-Flores N, Pérez-Sisqués L, Creus-Muncunill J, Masana M, Ginés S, Alberch J, Pérez-Navarro E, Malagelada C. Martín-Flores N, et al. Among authors: malagelada c. Cell Death Dis. 2020 Jul 30;11(7):569. doi: 10.1038/s41419-020-02775-5. Cell Death Dis. 2020. PMID: 32732871 Free PMC article.
RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer's disease.
Pérez-Sisqués L, Sancho-Balsells A, Solana-Balaguer J, Campoy-Campos G, Vives-Isern M, Soler-Palazón F, Anglada-Huguet M, López-Toledano MÁ, Mandelkow EM, Alberch J, Giralt A, Malagelada C. Pérez-Sisqués L, et al. Among authors: malagelada c. Cell Death Dis. 2021 Jun 15;12(6):616. doi: 10.1038/s41419-021-03899-y. Cell Death Dis. 2021. PMID: 34131105 Free PMC article.
RTP801/REDD1 Is Involved in Neuroinflammation and Modulates Cognitive Dysfunction in Huntington's Disease.
Pérez-Sisqués L, Solana-Balaguer J, Campoy-Campos G, Martín-Flores N, Sancho-Balsells A, Vives-Isern M, Soler-Palazón F, Garcia-Forn M, Masana M, Alberch J, Pérez-Navarro E, Giralt A, Malagelada C. Pérez-Sisqués L, et al. Among authors: malagelada c. Biomolecules. 2021 Dec 27;12(1):34. doi: 10.3390/biom12010034. Biomolecules. 2021. PMID: 35053183 Free PMC article.
Increased Phospho-AKT in Blood Cells from LRRK2 G2019S Mutation Carriers.
Garrido A, Pérez-Sisqués L, Simonet C, Campoy-Campos G, Solana-Balaguer J, Martín-Flores N, Fernández M, Soto M, Obiang D, Cámara A, Valldeoriola F, Muñoz E, Compta Y, Pérez-Navarro E, Alberch J, Tolosa E, Martí MJ, Ezquerra M, Malagelada C, Fernández-Santiago R. Garrido A, et al. Among authors: malagelada c. Ann Neurol. 2022 Nov;92(5):888-894. doi: 10.1002/ana.26469. Epub 2022 Sep 26. Ann Neurol. 2022. PMID: 35929078 Free PMC article.
Neuron-derived extracellular vesicles contain synaptic proteins, promote spine formation, activate TrkB-mediated signalling and preserve neuronal complexity.
Solana-Balaguer J, Campoy-Campos G, Martín-Flores N, Pérez-Sisqués L, Sitjà-Roqueta L, Kucukerden M, Gámez-Valero A, Coll-Manzano A, Martí E, Pérez-Navarro E, Alberch J, Soriano J, Masana M, Malagelada C. Solana-Balaguer J, et al. Among authors: malagelada c. J Extracell Vesicles. 2023 Sep;12(9):e12355. doi: 10.1002/jev2.12355. J Extracell Vesicles. 2023. PMID: 37743539 Free PMC article.
RTP801 mediates transneuronal toxicity in culture via extracellular vesicles.
Solana-Balaguer J, Martín-Flores N, Garcia-Segura P, Campoy-Campos G, Pérez-Sisqués L, Chicote-González A, Fernández-Irigoyen J, Santamaría E, Pérez-Navarro E, Alberch J, Malagelada C. Solana-Balaguer J, et al. Among authors: malagelada c. J Extracell Vesicles. 2023 Nov;12(11):e12378. doi: 10.1002/jev2.12378. J Extracell Vesicles. 2023. PMID: 37932242 Free PMC article.
97 results