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Small RNAs are modified with N-glycans and displayed on the surface of living cells.
Flynn RA, Pedram K, Malaker SA, Batista PJ, Smith BAH, Johnson AG, George BM, Majzoub K, Villalta PW, Carette JE, Bertozzi CR. Flynn RA, et al. Among authors: malaker sa. Cell. 2021 Jun 10;184(12):3109-3124.e22. doi: 10.1016/j.cell.2021.04.023. Epub 2021 May 17. Cell. 2021. PMID: 34004145 Free PMC article.
Mucus sialylation determines intestinal host-commensal homeostasis.
Yao Y, Kim G, Shafer S, Chen Z, Kubo S, Ji Y, Luo J, Yang W, Perner SP, Kanellopoulou C, Park AY, Jiang P, Li J, Baris S, Aydiner EK, Ertem D, Mulder DJ, Warner N, Griffiths AM, Topf-Olivestone C, Kori M, Werner L, Ouahed J, Field M, Liu C, Schwarz B, Bosio CM, Ganesan S, Song J, Urlaub H, Oellerich T, Malaker SA, Zheng L, Bertozzi CR, Zhang Y, Matthews H, Montgomery W, Shih HY, Jiang J, Jones M, Baras A, Shuldiner A, Gonzaga-Jauregui C, Snapper SB, Muise AM, Shouval DS, Ozen A, Pan KT, Wu C, Lenardo MJ. Yao Y, et al. Among authors: malaker sa. Cell. 2022 Mar 31;185(7):1172-1188.e28. doi: 10.1016/j.cell.2022.02.013. Epub 2022 Mar 17. Cell. 2022. PMID: 35303419 Free PMC article.
Targeted glycan degradation potentiates the anticancer immune response in vivo.
Gray MA, Stanczak MA, Mantuano NR, Xiao H, Pijnenborg JFA, Malaker SA, Miller CL, Weidenbacher PA, Tanzo JT, Ahn G, Woods EC, Läubli H, Bertozzi CR. Gray MA, et al. Among authors: malaker sa. Nat Chem Biol. 2020 Dec;16(12):1376-1384. doi: 10.1038/s41589-020-0622-x. Epub 2020 Aug 17. Nat Chem Biol. 2020. PMID: 32807964 Free PMC article.
Cell-specific bioorthogonal tagging of glycoproteins.
Cioce A, Calle B, Rizou T, Lowery SC, Bridgeman VL, Mahoney KE, Marchesi A, Bineva-Todd G, Flynn H, Li Z, Tastan OY, Roustan C, Soro-Barrio P, Rafiee MR, Garza-Garcia A, Antonopoulos A, Wood TM, Keenan T, Both P, Huang K, Parmeggian F, Snijders AP, Skehel M, Kjær S, Fascione MA, Bertozzi CR, Haslam SM, Flitsch SL, Malaker SA, Malanchi I, Schumann B. Cioce A, et al. Among authors: malaker sa. Nat Commun. 2022 Oct 25;13(1):6237. doi: 10.1038/s41467-022-33854-0. Nat Commun. 2022. PMID: 36284108 Free PMC article.
Glycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE.
Chongsaritsinsuk J, Steigmeyer AD, Mahoney KE, Rosenfeld MA, Lucas TM, Smith CM, Li A, Ince D, Kearns FL, Battison AS, Hollenhorst MA, Judy Shon D, Tiemeyer KH, Attah V, Kwon C, Bertozzi CR, Ferracane MJ, Lemmon MA, Amaro RE, Malaker SA. Chongsaritsinsuk J, et al. Among authors: malaker sa. Nat Commun. 2023 Oct 4;14(1):6169. doi: 10.1038/s41467-023-41756-y. Nat Commun. 2023. PMID: 37794035 Free PMC article.
Mucinomics as the Next Frontier of Mass Spectrometry.
Rangel-Angarita V, Malaker SA. Rangel-Angarita V, et al. Among authors: malaker sa. ACS Chem Biol. 2021 Oct 15;16(10):1866-1883. doi: 10.1021/acschembio.1c00384. Epub 2021 Jul 28. ACS Chem Biol. 2021. PMID: 34319686 Review.
Design of a mucin-selective protease for targeted degradation of cancer-associated mucins.
Pedram K, Shon DJ, Tender GS, Mantuano NR, Northey JJ, Metcalf KJ, Wisnovsky SP, Riley NM, Forcina GC, Malaker SA, Kuo A, George BM, Miller CL, Casey KM, Vilches-Moure JG, Ferracane MJ, Weaver VM, Läubli H, Bertozzi CR. Pedram K, et al. Among authors: malaker sa. Nat Biotechnol. 2024 Apr;42(4):597-607. doi: 10.1038/s41587-023-01840-6. Epub 2023 Aug 3. Nat Biotechnol. 2024. PMID: 37537499 Free PMC article.
Revealing the human mucinome.
Malaker SA, Riley NM, Shon DJ, Pedram K, Krishnan V, Dorigo O, Bertozzi CR. Malaker SA, et al. Nat Commun. 2022 Jun 20;13(1):3542. doi: 10.1038/s41467-022-31062-4. Nat Commun. 2022. PMID: 35725833 Free PMC article.
Comprehensive analysis of platelet glycoprotein Ibα ectodomain glycosylation.
Hollenhorst MA, Tiemeyer KH, Mahoney KE, Aoki K, Ishihara M, Lowery SC, Rangel-Angarita V, Bertozzi CR, Malaker SA. Hollenhorst MA, et al. Among authors: malaker sa. J Thromb Haemost. 2023 Apr;21(4):995-1009. doi: 10.1016/j.jtha.2023.01.009. Epub 2023 Jan 14. J Thromb Haemost. 2023. PMID: 36740532 Free PMC article.
45 results