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Synthesis and evaluation of potent and selective MGL inhibitors as a glaucoma treatment.
Alapafuja SO, Malamas MS, Shukla V, Zvonok A, Miller S, Daily L, Rajarshi G, Miyabe CY, Chandrashekhar H, Wood J, Tyukhtenko S, Straiker A, Makriyannis A. Alapafuja SO, et al. Among authors: malamas ms. Bioorg Med Chem. 2019 Jan 1;27(1):55-64. doi: 10.1016/j.bmc.2018.11.003. Epub 2018 Nov 3. Bioorg Med Chem. 2019. PMID: 30446439 Free PMC article.
Design and Structure-Activity Relationships of Isothiocyanates as Potent and Selective N-Acylethanolamine-Hydrolyzing Acid Amidase Inhibitors.
Malamas MS, Pavlopoulos S, Alapafuja SO, Farah SI, Zvonok A, Mohammad KA, West J, Perry NT, Pelekoudas DN, Rajarshi G, Shields C, Chandrashekhar H, Wood J, Makriyannis A. Malamas MS, et al. J Med Chem. 2021 May 13;64(9):5956-5972. doi: 10.1021/acs.jmedchem.1c00076. Epub 2021 Apr 26. J Med Chem. 2021. PMID: 33900772
Design and Synthesis of Highly Potent and Specific ABHD6 Inhibitors.
Malamas MS, Lamani M, Farah SI, Mohammad KA, Miyabe CY, Rajarshi G, Wu S, Zvonok N, Chandrashekhar H, Wood J, Makriyannis A. Malamas MS, et al. ChemMedChem. 2023 Nov 2;18(21):e202100406. doi: 10.1002/cmdc.202100406. Epub 2021 Sep 6. ChemMedChem. 2023. PMID: 34486233
N-Acylethanolamine-Hydrolyzing Acid Amidase Inhibition, but Not Fatty Acid Amide Hydrolase Inhibition, Prevents the Development of Experimental Autoimmune Encephalomyelitis in Mice.
Bottemanne P, Guillemot-Legris O, Paquot A, Masquelier J, Malamas M, Makriyannis A, Alhouayek M, Muccioli GG. Bottemanne P, et al. Neurotherapeutics. 2021 Jul;18(3):1815-1833. doi: 10.1007/s13311-021-01074-x. Epub 2021 Jul 7. Neurotherapeutics. 2021. PMID: 34235639 Free PMC article.
The endocannabinoid 2-arachidonoylglycerol and dual ABHD6/MAGL enzyme inhibitors display neuroprotective and anti-inflammatory actions in the in vivo retinal model of AMPA excitotoxicity.
Kokona D, Spyridakos D, Tzatzarakis M, Papadogkonaki S, Filidou E, Arvanitidis KI, Kolios G, Lamani M, Makriyannis A, Malamas MS, Thermos K. Kokona D, et al. Among authors: malamas ms. Neuropharmacology. 2021 Mar 1;185:108450. doi: 10.1016/j.neuropharm.2021.108450. Epub 2021 Jan 12. Neuropharmacology. 2021. PMID: 33450278
57 results