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Contact-dependent growth inhibition requires the essential outer membrane protein BamA (YaeT) as the receptor and the inner membrane transport protein AcrB.
Aoki SK, Malinverni JC, Jacoby K, Thomas B, Pamma R, Trinh BN, Remers S, Webb J, Braaten BA, Silhavy TJ, Low DA. Aoki SK, et al. Among authors: malinverni jc. Mol Microbiol. 2008 Oct;70(2):323-40. doi: 10.1111/j.1365-2958.2008.06404.x. Epub 2008 Aug 22. Mol Microbiol. 2008. PMID: 18761695 Free PMC article.
Inhibitor of intramembrane protease RseP blocks the σE response causing lethal accumulation of unfolded outer membrane proteins.
Konovalova A, Grabowicz M, Balibar CJ, Malinverni JC, Painter RE, Riley D, Mann PA, Wang H, Garlisi CG, Sherborne B, Rigel NW, Ricci DP, Black TA, Roemer T, Silhavy TJ, Walker SS. Konovalova A, et al. Among authors: malinverni jc. Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6614-E6621. doi: 10.1073/pnas.1806107115. Epub 2018 Jun 25. Proc Natl Acad Sci U S A. 2018. PMID: 29941590 Free PMC article.
A small-molecule inhibitor of BamA impervious to efflux and the outer membrane permeability barrier.
Hart EM, Mitchell AM, Konovalova A, Grabowicz M, Sheng J, Han X, Rodriguez-Rivera FP, Schwaid AG, Malinverni JC, Balibar CJ, Bodea S, Si Q, Wang H, Homsher MF, Painter RE, Ogawa AK, Sutterlin H, Roemer T, Black TA, Rothman DM, Walker SS, Silhavy TJ. Hart EM, et al. Among authors: malinverni jc. Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21748-21757. doi: 10.1073/pnas.1912345116. Epub 2019 Oct 7. Proc Natl Acad Sci U S A. 2019. PMID: 31591200 Free PMC article.
Folding LacZ in the periplasm of Escherichia coli.
Dwyer RS, Malinverni JC, Boyd D, Beckwith J, Silhavy TJ. Dwyer RS, et al. Among authors: malinverni jc. J Bacteriol. 2014 Sep;196(18):3343-50. doi: 10.1128/JB.01843-14. Epub 2014 Jul 7. J Bacteriol. 2014. PMID: 25002543 Free PMC article.
15 results