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Page 1
RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury.
Newton K, Dugger DL, Maltzman A, Greve JM, Hedehus M, Martin-McNulty B, Carano RA, Cao TC, van Bruggen N, Bernstein L, Lee WP, Wu X, DeVoss J, Zhang J, Jeet S, Peng I, McKenzie BS, Roose-Girma M, Caplazi P, Diehl L, Webster JD, Vucic D. Newton K, et al. Among authors: maltzman a. Cell Death Differ. 2016 Sep 1;23(9):1565-76. doi: 10.1038/cdd.2016.46. Epub 2016 May 13. Cell Death Differ. 2016. PMID: 27177019 Free PMC article.
RIPK1 inhibits ZBP1-driven necroptosis during development.
Newton K, Wickliffe KE, Maltzman A, Dugger DL, Strasser A, Pham VC, Lill JR, Roose-Girma M, Warming S, Solon M, Ngu H, Webster JD, Dixit VM. Newton K, et al. Among authors: maltzman a. Nature. 2016 Dec 1;540(7631):129-133. doi: 10.1038/nature20559. Epub 2016 Nov 7. Nature. 2016. PMID: 27819682
RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases.
Patel S, Webster JD, Varfolomeev E, Kwon YC, Cheng JH, Zhang J, Dugger DL, Wickliffe KE, Maltzman A, Sujatha-Bhaskar S, Bir Kohli P, Ramaswamy S, Deshmukh G, Liederer BM, Fong R, Hamilton G, Lupardus P, Caplazi P, Lee WP, van Lookeren Campagne M, Johnson A, McKenzie BS, Junttila MR, Newton K, Vucic D. Patel S, et al. Among authors: maltzman a. Cell Death Differ. 2020 Jan;27(1):161-175. doi: 10.1038/s41418-019-0347-0. Epub 2019 May 17. Cell Death Differ. 2020. PMID: 31101885 Free PMC article.
OTULIN limits cell death and inflammation by deubiquitinating LUBAC.
Heger K, Wickliffe KE, Ndoja A, Zhang J, Murthy A, Dugger DL, Maltzman A, de Sousa E Melo F, Hung J, Zeng Y, Verschueren E, Kirkpatrick DS, Vucic D, Lee WP, Roose-Girma M, Newman RJ, Warming S, Hsiao YC, Kőműves LG, Webster JD, Newton K, Dixit VM. Heger K, et al. Among authors: maltzman a. Nature. 2018 Jul;559(7712):120-124. doi: 10.1038/s41586-018-0256-2. Epub 2018 Jun 27. Nature. 2018. PMID: 29950720
Activity of caspase-8 determines plasticity between cell death pathways.
Newton K, Wickliffe KE, Maltzman A, Dugger DL, Reja R, Zhang Y, Roose-Girma M, Modrusan Z, Sagolla MS, Webster JD, Dixit VM. Newton K, et al. Among authors: maltzman a. Nature. 2019 Nov;575(7784):679-682. doi: 10.1038/s41586-019-1752-8. Epub 2019 Nov 13. Nature. 2019. PMID: 31723262
The RIPK4-IRF6 signalling axis safeguards epidermal differentiation and barrier function.
Oberbeck N, Pham VC, Webster JD, Reja R, Huang CS, Zhang Y, Roose-Girma M, Warming S, Li Q, Birnberg A, Wong W, Sandoval W, Kőműves LG, Yu K, Dugger DL, Maltzman A, Newton K, Dixit VM. Oberbeck N, et al. Among authors: maltzman a. Nature. 2019 Oct;574(7777):249-253. doi: 10.1038/s41586-019-1615-3. Epub 2019 Oct 2. Nature. 2019. PMID: 31578523
NLRP3 recruitment by NLRC4 during Salmonella infection.
Qu Y, Misaghi S, Newton K, Maltzman A, Izrael-Tomasevic A, Arnott D, Dixit VM. Qu Y, et al. Among authors: maltzman a. J Exp Med. 2016 May 30;213(6):877-85. doi: 10.1084/jem.20132234. Epub 2016 May 2. J Exp Med. 2016. PMID: 27139490 Free PMC article.
N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation.
Gitlin AD, Maltzman A, Kanno Y, Heger K, Reja R, Schubert AF, Wierciszewski LJ, Pantua H, Kapadia SB, Harris SF, Webster JD, Newton K, Dixit VM. Gitlin AD, et al. Among authors: maltzman a. Immunity. 2024 Apr 26:S1074-7613(24)00209-7. doi: 10.1016/j.immuni.2024.04.004. Online ahead of print. Immunity. 2024. PMID: 38697117
ZBP1 and TRIF trigger lethal necroptosis in mice lacking caspase-8 and TNFR1.
Solon M, Ge N, Hambro S, Haller S, Jiang J, Baca M, Preston J, Maltzman A, Wickliffe KE, Liang Y, Reja R, Nickles D, Newton K, Webster JD. Solon M, et al. Among authors: maltzman a. Cell Death Differ. 2024 Mar 28. doi: 10.1038/s41418-024-01286-6. Online ahead of print. Cell Death Differ. 2024. PMID: 38548850
11 results