Inflammatory and age-related pathologies in mice with ectopic expression of human PARP-1.
Mangerich A, Herbach N, Hanf B, Fischbach A, Popp O, Moreno-Villanueva M, Bruns OT, Bürkle A.
Mangerich A, et al.
Mech Ageing Dev. 2010 Jun;131(6):389-404. doi: 10.1016/j.mad.2010.05.005. Epub 2010 Jun 8.
Mech Ageing Dev. 2010.
PMID: 20561897
PARP-1 is involved in the regulation of genomic integrity, transcription, inflammation, and cell death. Due to its versatile role, PARP-1 is discussed both as a longevity factor and as an aging-promoting factor. Recently, we generated a mouse model with ectopic inte …
PARP-1 is involved in the regulation of genomic integrity, transcription, inflammation, and cell death. Due to its versatile role, PARP-1 is …