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Lisaftoclax (APG-2575) Is a Novel BCL-2 Inhibitor with Robust Antitumor Activity in Preclinical Models of Hematologic Malignancy.
Deng J, Paulus A, Fang DD, Manna A, Wang G, Wang H, Zhu S, Chen J, Min P, Yin Y, Dutta N, Halder N, Ciccio G, Copland JA, Miller J, Han B, Bai L, Liu L, Wang M, McEachern D, Przybranowski S, Yang CY, Stuckey JA, Wu D, Li C, Ryan J, Letai A, Ailawadhi S, Yang D, Wang S, Chanan-Khan A, Zhai Y. Deng J, et al. Among authors: manna a. Clin Cancer Res. 2022 Dec 15;28(24):5455-5468. doi: 10.1158/1078-0432.CCR-21-4037. Clin Cancer Res. 2022. PMID: 36048524
Targeting CD38 Enhances the Antileukemic Activity of Ibrutinib in Chronic Lymphocytic Leukemia.
Manna A, Aulakh S, Jani P, Ahmed S, Akhtar S, Coignet M, Heckman M, Meghji Z, Bhatia K, Sharma A, Sher T, Alegria V, Malavasi F, Chini EN, Chanan-Khan A, Ailawadhi S, Paulus A. Manna A, et al. Clin Cancer Res. 2019 Jul 1;25(13):3974-3985. doi: 10.1158/1078-0432.CCR-18-3412. Epub 2019 Apr 2. Clin Cancer Res. 2019. PMID: 30940652 Free PMC article.
Survival trends in glioblastoma and association with treating facility volume.
Aulakh S, DeDeo MR, Free J, Rosenfeld SS, Quinones-Hinojosa A, Paulus A, Manna A, Manochakian R, Chanan-Khan AA, Ailawadhi S. Aulakh S, et al. Among authors: manna a. J Clin Neurosci. 2019 Oct;68:271-274. doi: 10.1016/j.jocn.2019.04.028. Epub 2019 May 24. J Clin Neurosci. 2019. PMID: 31133366 Free PMC article.
Novel tumor-targeted liposomes comprised of an MDM2 antagonist plus proteasome inhibitor display anti-tumor activity in a xenograft model of bortezomib-resistant Waldenstrom macroglobulinemia.
Madamsetty VS, Paulus A, Akhtar S, Manna A, Rachamalla HR, Banerjee R, Mukhopadhyay D, Chanan-Khan A. Madamsetty VS, et al. Among authors: manna a. Leuk Lymphoma. 2020 Oct;61(10):2399-2408. doi: 10.1080/10428194.2020.1775204. Epub 2020 Jun 19. Leuk Lymphoma. 2020. PMID: 32558607
Waldenstrom macroglobulinemia cells devoid of BTKC481S or CXCR4WHIM-like mutations acquire resistance to ibrutinib through upregulation of Bcl-2 and AKT resulting in vulnerability towards venetoclax or MK2206 treatment.
Paulus A, Akhtar S, Yousaf H, Manna A, Paulus SM, Bashir Y, Caulfield TR, Kuranz-Blake M, Chitta K, Wang X, Asmann Y, Hudec R, Springer W, Ailawadhi S, Chanan-Khan A. Paulus A, et al. Among authors: manna a. Blood Cancer J. 2017 May 26;7(5):e565. doi: 10.1038/bcj.2017.40. Blood Cancer J. 2017. PMID: 28548645 Free PMC article.
Targeting CD38 with daratumumab is lethal to Waldenström macroglobulinaemia cells.
Paulus A, Manna A, Akhtar S, Paulus SM, Sharma M, Coignet MV, Jiang L, Roy V, Witzig TE, Ansell SM, Allan J, Furman R, Aulakh S, Manochakian R, Ailawadhi S, Chanan-Khan AA, Sher T. Paulus A, et al. Among authors: manna a. Br J Haematol. 2018 Oct;183(2):196-211. doi: 10.1111/bjh.15515. Epub 2018 Aug 6. Br J Haematol. 2018. PMID: 30080238 Free PMC article.
Prospect of CAR T-cell therapy in acute myeloid leukemia.
Badar T, Manna A, Gadd ME, Kharfan-Dabaja MA, Qin H. Badar T, et al. Among authors: manna a. Expert Opin Investig Drugs. 2022 Feb;31(2):211-220. doi: 10.1080/13543784.2022.2032642. Epub 2022 Jan 24. Expert Opin Investig Drugs. 2022. PMID: 35051347
792 results