Manning BD - Search Results

1

Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.

Menon S, Dibble CC, Talbott G, Hoxhaj G, Valvezan AJ, Takahashi H, Cantley LC, Manning BD. Menon S, et al. Among authors: manning bd. Cell. 2014 Feb 13;156(4):771-85. doi: 10.1016/j.cell.2013.11.049. Cell. 2014. PMID: 24529379 Free PMC article.

2

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.

Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC. Manning BD, et al. Mol Cell. 2002 Jul;10(1):151-62. doi: 10.1016/s1097-2765(02)00568-3. Mol Cell. 2002. PMID: 12150915 Free article.

3

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.

Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J. Tee AR, et al. Among authors: manning bd. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13571-6. doi: 10.1073/pnas.202476899. Epub 2002 Sep 23. Proc Natl Acad Sci U S A. 2002. PMID: 12271141 Free PMC article.

4

Hitting the target: emerging technologies in the search for kinase substrates.

Manning BD, Cantley LC. Manning BD, et al. Sci STKE. 2002 Dec 10;2002(162):pe49. doi: 10.1126/stke.2002.162.pe49. Sci STKE. 2002. PMID: 12475999 Review.

5

United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling.

Manning BD, Cantley LC. Manning BD, et al. Biochem Soc Trans. 2003 Jun;31(Pt 3):573-8. doi: 10.1042/bst0310573. Biochem Soc Trans. 2003. PMID: 12773158 Review.

6

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.

Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J. Tee AR, et al. Among authors: manning bd. Curr Biol. 2003 Aug 5;13(15):1259-68. doi: 10.1016/s0960-9822(03)00506-2. Curr Biol. 2003. PMID: 12906785 Free article.

7

Targeting the PI3K-Akt pathway in human cancer: rationale and promise.

Luo J, Manning BD, Cantley LC. Luo J, et al. Among authors: manning bd. Cancer Cell. 2003 Oct;4(4):257-62. doi: 10.1016/s1535-6108(03)00248-4. Cancer Cell. 2003. PMID: 14585353 Free article. Review. No abstract available.

8

Rheb fills a GAP between TSC and TOR.

Manning BD, Cantley LC. Manning BD, et al. Trends Biochem Sci. 2003 Nov;28(11):573-6. doi: 10.1016/j.tibs.2003.09.003. Trends Biochem Sci. 2003. PMID: 14607085 Review.

9

The LKB1 tumor suppressor negatively regulates mTOR signaling.

Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC. Shaw RJ, et al. Among authors: manning bd. Cancer Cell. 2004 Jul;6(1):91-9. doi: 10.1016/j.ccr.2004.06.007. Cancer Cell. 2004. PMID: 15261145 Free article.

10

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis.

Manning BD. Manning BD. J Cell Biol. 2004 Nov 8;167(3):399-403. doi: 10.1083/jcb.200408161. J Cell Biol. 2004. PMID: 15533996 Free PMC article. Review.

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