Manning BD - Search Results

1

Direct stimulation of NADP⁺ synthesis through Akt-mediated phosphorylation of NAD kinase.

Hoxhaj G, Ben-Sahra I, Lockwood SE, Timson RC, Byles V, Henning GT, Gao P, Selfors LM, Asara JM, Manning BD. Hoxhaj G, et al. Among authors: manning bd. Science. 2019 Mar 8;363(6431):1088-1092. doi: 10.1126/science.aau3903. Science. 2019. PMID: 30846598 Free PMC article.

2

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.

Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC. Manning BD, et al. Mol Cell. 2002 Jul;10(1):151-62. doi: 10.1016/s1097-2765(02)00568-3. Mol Cell. 2002. PMID: 12150915 Free article.

3

United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling.

Manning BD, Cantley LC. Manning BD, et al. Biochem Soc Trans. 2003 Jun;31(Pt 3):573-8. doi: 10.1042/bst0310573. Biochem Soc Trans. 2003. PMID: 12773158 Review.

4

S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt.

Zhang HH, Lipovsky AI, Dibble CC, Sahin M, Manning BD. Zhang HH, et al. Among authors: manning bd. Mol Cell. 2006 Oct 20;24(2):185-97. doi: 10.1016/j.molcel.2006.09.019. Mol Cell. 2006. PMID: 17052453 Free PMC article.

5

A complex interplay between Akt, TSC2 and the two mTOR complexes.

Huang J, Manning BD. Huang J, et al. Among authors: manning bd. Biochem Soc Trans. 2009 Feb;37(Pt 1):217-22. doi: 10.1042/BST0370217. Biochem Soc Trans. 2009. PMID: 19143635 Free PMC article. Review.

6

Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1.

Dibble CC, Asara JM, Manning BD. Dibble CC, et al. Among authors: manning bd. Mol Cell Biol. 2009 Nov;29(21):5657-70. doi: 10.1128/MCB.00735-09. Epub 2009 Aug 31. Mol Cell Biol. 2009. PMID: 19720745 Free PMC article.

7

TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1.

Dibble CC, Elis W, Menon S, Qin W, Klekota J, Asara JM, Finan PM, Kwiatkowski DJ, Murphy LO, Manning BD. Dibble CC, et al. Among authors: manning bd. Mol Cell. 2012 Aug 24;47(4):535-46. doi: 10.1016/j.molcel.2012.06.009. Epub 2012 Jul 12. Mol Cell. 2012. PMID: 22795129 Free PMC article.

8

Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.

Ben-Sahra I, Howell JJ, Asara JM, Manning BD. Ben-Sahra I, et al. Among authors: manning bd. Science. 2013 Mar 15;339(6125):1323-8. doi: 10.1126/science.1228792. Epub 2013 Feb 21. Science. 2013. PMID: 23429703 Free PMC article.

9

Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer.

Liu Y, Marks K, Cowley GS, Carretero J, Liu Q, Nieland TJ, Xu C, Cohoon TJ, Gao P, Zhang Y, Chen Z, Altabef AB, Tchaicha JH, Wang X, Choe S, Driggers EM, Zhang J, Bailey ST, Sharpless NE, Hayes DN, Patel NM, Janne PA, Bardeesy N, Engelman JA, Manning BD, Shaw RJ, Asara JM, Scully R, Kimmelman A, Byers LA, Gibbons DL, Wistuba II, Heymach JV, Kwiatkowski DJ, Kim WY, Kung AL, Gray NS, Root DE, Cantley LC, Wong KK. Liu Y, et al. Among authors: manning bd. Cancer Discov. 2013 Aug;3(8):870-9. doi: 10.1158/2159-8290.CD-13-0015. Epub 2013 May 28. Cancer Discov. 2013. PMID: 23715154 Free PMC article.

10

A growing role for mTOR in promoting anabolic metabolism.

Howell JJ, Ricoult SJ, Ben-Sahra I, Manning BD. Howell JJ, et al. Among authors: manning bd. Biochem Soc Trans. 2013 Aug;41(4):906-12. doi: 10.1042/BST20130041. Biochem Soc Trans. 2013. PMID: 23863154 Review.

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