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Cannabidiol disrupts tryptophan metabolism in the human term placenta.
Portillo R, Abad C, Synova T, Kastner P, Daniel H, Kucera R, Karahoda R, Staud F. Portillo R, et al. Toxicology. 2024 Apr 23:153813. doi: 10.1016/j.tox.2024.153813. Online ahead of print. Toxicology. 2024. PMID: 38663822
Explants were exposed to CBD at therapeutic (0.1, 1, 2.5mug/ml) and non-therapeutic (20 and 40mug/ml) concentrations to determine its effects on the gene and protein expression of key enzymes in TRP metabolism and metabolite release. CBD upregulated TRP hydroxylase (TPH) and down …
Explants were exposed to CBD at therapeutic (0.1, 1, 2.5mug/ml) and non-therapeutic (20 and 40mug/ml) concentrations to determine its effect …
PINK1 Type of Young-Onset Parkinson Disease.
Lange LM, Klein C. Lange LM, et al. 2010 Mar 16 [updated 2024 Apr 25]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2010 Mar 16 [updated 2024 Apr 25]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 20301792 Free Books & Documents. Review.
MANAGEMENT: Treatment of manifestations: PINK1 type of young-onset Parkinson disease usually responds well to L-dopa and/or other dopamine agonists, which may be used in combination with catechol-O-methyltransferase inhibitors or monoamine oxidase-B inhibitors, anti …
MANAGEMENT: Treatment of manifestations: PINK1 type of young-onset Parkinson disease usually responds well to L-dopa and/or other dopamine a …
Residues of chlorpyrifos in the environment induce resistance in Aedes albopictus by affecting its olfactory system and neurotoxicity.
Chen Y, Zhang C, Li W, Lan R, Chen R, Hu J, Yang C, Wang P, Tang B, Wang S. Chen Y, et al. Sci Total Environ. 2024 Apr 19:172425. doi: 10.1016/j.scitotenv.2024.172425. Online ahead of print. Sci Total Environ. 2024. PMID: 38643874
We assessed Ca(2+)-Mg(2+)-ATP levels, choline acetyltransferase (ChAT), Monoamine oxidase (MAO), odorant-binding proteins (OBPs), and olfactory receptor (OR7) gene expression in Ae. albopictus using various assays including Y-shaped tube experiments and DanioVision …
We assessed Ca(2+)-Mg(2+)-ATP levels, choline acetyltransferase (ChAT), Monoamine oxidase (MAO), odorant-binding proteins (OBP …
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