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Synthesis and Monoamine Oxidase Inhibitory Activity of Halogenated Flavones.
Castillo-Arellano JI, Stryker Z, Wyatt MD, León F. Castillo-Arellano JI, et al. ACS Med Chem Lett. 2024 Apr 3;15(5):610-618. doi: 10.1021/acsmedchemlett.3c00573. eCollection 2024 May 9. ACS Med Chem Lett. 2024. PMID: 38746894
Small molecule neurotransmitters containing amines are metabolized by monoamine oxidase (MAO) in the nervous system. Monoamine oxidase inhibitors are a valuable class of drugs prescribed for the management of neurological disorders, including depressio …
Small molecule neurotransmitters containing amines are metabolized by monoamine oxidase (MAO) in the nervous system. Monoam
In vitro and in vivo metabolism of psilocybin's active metabolite psilocin.
Thomann J, Kolaczynska KE, Stoeckmann OV, Rudin D, Vizeli P, Hoener MC, Pryce CR, Vollenweider FX, Liechti ME, Duthaler U. Thomann J, et al. Front Pharmacol. 2024 Apr 29;15:1391689. doi: 10.3389/fphar.2024.1391689. eCollection 2024. Front Pharmacol. 2024. PMID: 38741590 Free PMC article.
Metabolism studies were performed using human liver microsomes (HLM), cytochrome P450 (CYP) enzymes, monoamine oxidase (MAO), and UDP-glucuronosyltransferase (UGT). In vivo, metabolism was examined using male C57BL/6J mice and human plasma samples. ...
Metabolism studies were performed using human liver microsomes (HLM), cytochrome P450 (CYP) enzymes, monoamine oxidase (MAO), …
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