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Fumarate induces vesicular release of mtDNA to drive innate immunity.
Zecchini V, Paupe V, Herranz-Montoya I, Janssen J, Wortel IMN, Morris JL, Ferguson A, Chowdury SR, Segarra-Mondejar M, Costa ASH, Pereira GC, Tronci L, Young T, Nikitopoulou E, Yang M, Bihary D, Caicci F, Nagashima S, Speed A, Bokea K, Baig Z, Samarajiwa S, Tran M, Mitchell T, Johnson M, Prudent J, Frezza C. Zecchini V, et al. Among authors: segarra mondejar m. Nature. 2023 Mar;615(7952):499-506. doi: 10.1038/s41586-023-05770-w. Epub 2023 Mar 8. Nature. 2023. PMID: 36890229 Free PMC article.
FOXA2 controls the anti-oxidant response in FH-deficient cells.
Rogerson C, Sciacovelli M, Maddalena LA, Pouikli A, Segarra-Mondejar M, Valcarcel-Jimenez L, Schmidt C, Yang M, Ivanova E, Kent J, Mora A, Cheeseman D, Carroll JS, Kelsey G, Frezza C. Rogerson C, et al. Among authors: segarra mondejar m. Cell Rep. 2023 Jul 25;42(7):112751. doi: 10.1016/j.celrep.2023.112751. Epub 2023 Jul 4. Cell Rep. 2023. PMID: 37405921 Free PMC article.
Mfn2 localization in the ER is necessary for its bioenergetic function and neuritic development.
Casellas-Díaz S, Larramona-Arcas R, Riqué-Pujol G, Tena-Morraja P, Müller-Sánchez C, Segarra-Mondejar M, Gavaldà-Navarro A, Villarroya F, Reina M, Martínez-Estrada OM, Soriano FX. Casellas-Díaz S, et al. Among authors: segarra mondejar m. EMBO Rep. 2021 Sep 6;22(9):e51954. doi: 10.15252/embr.202051954. Epub 2021 Jul 23. EMBO Rep. 2021. PMID: 34296790 Free PMC article.
Mitochondrial fragmentation in excitotoxicity requires ROCK activation.
Martorell-Riera A, Segarra-Mondejar M, Reina M, Martínez-Estrada OM, Soriano FX. Martorell-Riera A, et al. Among authors: segarra mondejar m. Cell Cycle. 2015;14(9):1365-9. doi: 10.1080/15384101.2015.1022698. Cell Cycle. 2015. PMID: 25789413 Free PMC article.
Epicardial cell shape and maturation are regulated by Wt1 via transcriptional control of Bmp4.
Velecela V, Torres-Cano A, García-Melero A, Ramiro-Pareta M, Müller-Sánchez C, Segarra-Mondejar M, Chau YY, Campos-Bonilla B, Reina M, Soriano FX, Hastie ND, Martínez FO, Martínez-Estrada OM. Velecela V, et al. Among authors: segarra mondejar m. Development. 2019 Oct 17;146(20):dev178723. doi: 10.1242/dev.178723. Development. 2019. PMID: 31624071