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DPP-4 is expressed in human pancreatic beta cells and its direct inhibition improves beta cell function and survival in type 2 diabetes.
Bugliani M, Syed F, Paula FMM, Omar BA, Suleiman M, Mossuto S, Grano F, Cardarelli F, Boggi U, Vistoli F, Filipponi F, De Simone P, Marselli L, De Tata V, Ahren B, Eizirik DL, Marchetti P. Bugliani M, et al. Among authors: marchetti p. Mol Cell Endocrinol. 2018 Sep 15;473:186-193. doi: 10.1016/j.mce.2018.01.019. Epub 2018 Feb 1. Mol Cell Endocrinol. 2018. PMID: 29409957
Pancreatic glucagon damages isolated human islet function.
Marchetti P, Lupi R, Lorenzetti M, Giannarelli R, Del Guerra S, Tellini C, Coppelli A, Lencioni C, Marselli L, Carmellini M, Mosca F, Navalesi R. Marchetti P, et al. Transplant Proc. 1998 Mar;30(2):397. doi: 10.1016/s0041-1345(97)01338-9. Transplant Proc. 1998. PMID: 9532099 No abstract available.
Effects of prolonged exposure to pancreatic glucagon on the function, antigenicity and survival of isolated human islets.
Del Guerra S, Lupi R, Dotta F, Marselli L, Lencioni C, Santangelo C, Realacci M, Carmellini M, Mosca F, Navalesi R, Marchetti P. Del Guerra S, et al. Among authors: marchetti p. Diabetes Metab Res Rev. 2000 Jul-Aug;16(4):281-6. doi: 10.1002/1520-7560(2000)9999:9999<::aid-dmrr124>3.0.co;2-q. Diabetes Metab Res Rev. 2000. PMID: 10934457
Th2 cytokines have a partial, direct protective effect on the function and survival of isolated human islets exposed to combined proinflammatory and Th1 cytokines.
Marselli L, Dotta F, Piro S, Santangelo C, Masini M, Lupi R, Realacci M, del Guerra S, Mosca F, Boggi U, Purrello F, Navalesi R, Marchetti P. Marselli L, et al. Among authors: marchetti p. J Clin Endocrinol Metab. 2001 Oct;86(10):4974-8. doi: 10.1210/jcem.86.10.7938. J Clin Endocrinol Metab. 2001. PMID: 11600573
NGF-withdrawal induces apoptosis in pancreatic beta cells in vitro.
Pierucci D, Cicconi S, Bonini P, Ferrelli F, Pastore D, Matteucci C, Marselli L, Marchetti P, Ris F, Halban P, Oberholzer J, Federici M, Cozzolino F, Lauro R, Borboni P, Marlier LN. Pierucci D, et al. Among authors: marchetti p. Diabetologia. 2001 Oct;44(10):1281-95. doi: 10.1007/s001250100650. Diabetologia. 2001. PMID: 11692177
1,442 results