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Identification of pyridazin-3-one derivatives as potent, selective histamine H₃ receptor inverse agonists with robust wake activity.
Hudkins RL, Aimone LD, Bailey TR, Bendesky RJ, Dandu RR, Dunn D, Gruner JA, Josef KA, Lin YG, Lyons J, Marcy VR, Mathiasen JR, Sundar BG, Tao M, Zulli AL, Raddatz R, Bacon ER. Hudkins RL, et al. Among authors: marcy vr. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5493-7. doi: 10.1016/j.bmcl.2011.06.108. Epub 2011 Jun 30. Bioorg Med Chem Lett. 2011. PMID: 21782432
Synthesis and evaluation of pyridazinone-phenethylamine derivatives as selective and orally bioavailable histamine H3 receptor antagonists with robust wake-promoting activity.
Dandu RR, Gruner JA, Mathiasen JR, Aimone LD, Hostetler G, Benfield C, Bendesky RJ, Marcy VR, Raddatz R, Hudkins RL. Dandu RR, et al. Among authors: marcy vr. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6362-5. doi: 10.1016/j.bmcl.2011.08.104. Epub 2011 Sep 1. Bioorg Med Chem Lett. 2011. PMID: 21944855
Wake-promoting agents: search for next generation modafinil: part IV.
Louvet P, Schweizer D, Gourdel ME, Riguet E, Yue C, Marcy VR, Lin YG, Gruner J, Lesur B, Bacon ER, Chatterjee S. Louvet P, et al. Among authors: marcy vr. Eur J Med Chem. 2012 Aug;54:949-51. doi: 10.1016/j.ejmech.2012.05.038. Epub 2012 Jun 8. Eur J Med Chem. 2012. PMID: 22749190
Aryl-heteroaryl derivatives as novel wake-promoting agents.
Lesur B, Lin YG, Marcy VR, Aimone LD, Gruner J, Bacon ER, Chatterjee S. Lesur B, et al. Among authors: marcy vr. Chem Biol Drug Des. 2013 Mar;81(3):429-32. doi: 10.1111/cbdd.12083. Epub 2012 Dec 26. Chem Biol Drug Des. 2013. PMID: 23110414
Activation of p38MAPK in microglia after ischemia.
Walton KM, DiRocco R, Bartlett BA, Koury E, Marcy VR, Jarvis B, Schaefer EM, Bhat RV. Walton KM, et al. Among authors: marcy vr. J Neurochem. 1998 Apr;70(4):1764-7. doi: 10.1046/j.1471-4159.1998.70041764.x. J Neurochem. 1998. PMID: 9523596 Free article.
17 results