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Page 1
Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation.
Lin L, DeMartino J, Wang D, van Son GJF, van der Linden R, Begthel H, Korving J, Andersson-Rolf A, van den Brink S, Lopez-Iglesias C, van de Wetering WJ, Balwierz A, Margaritis T, van de Wetering M, Peters PJ, Drost J, van Es JH, Clevers H. Lin L, et al. Among authors: margaritis t. Science. 2023 Oct 27;382(6669):451-458. doi: 10.1126/science.adi2246. Epub 2023 Oct 26. Science. 2023. PMID: 37883554
Functional overlap and regulatory links shape genetic interactions between signaling pathways.
van Wageningen S, Kemmeren P, Lijnzaad P, Margaritis T, Benschop JJ, de Castro IJ, van Leenen D, Groot Koerkamp MJ, Ko CW, Miles AJ, Brabers N, Brok MO, Lenstra TL, Fiedler D, Fokkens L, Aldecoa R, Apweiler E, Taliadouros V, Sameith K, van de Pasch LA, van Hooff SR, Bakker LV, Krogan NJ, Snel B, Holstege FC. van Wageningen S, et al. Among authors: margaritis t. Cell. 2010 Dec 10;143(6):991-1004. doi: 10.1016/j.cell.2010.11.021. Cell. 2010. PMID: 21145464 Free PMC article.
Poised RNA polymerase II gives pause for thought.
Margaritis T, Holstege FC. Margaritis T, et al. Cell. 2008 May 16;133(4):581-4. doi: 10.1016/j.cell.2008.04.027. Cell. 2008. PMID: 18485867 Free article. Review.
Tubuloids derived from human adult kidney and urine for personalized disease modeling.
Schutgens F, Rookmaaker MB, Margaritis T, Rios A, Ammerlaan C, Jansen J, Gijzen L, Vormann M, Vonk A, Viveen M, Yengej FY, Derakhshan S, de Winter-de Groot KM, Artegiani B, van Boxtel R, Cuppen E, Hendrickx APA, van den Heuvel-Eibrink MM, Heitzer E, Lanz H, Beekman J, Murk JL, Masereeuw R, Holstege F, Drost J, Verhaar MC, Clevers H. Schutgens F, et al. Among authors: margaritis t. Nat Biotechnol. 2019 Mar;37(3):303-313. doi: 10.1038/s41587-019-0048-8. Epub 2019 Mar 4. Nat Biotechnol. 2019. PMID: 30833775
An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity.
Calandrini C, Schutgens F, Oka R, Margaritis T, Candelli T, Mathijsen L, Ammerlaan C, van Ineveld RL, Derakhshan S, de Haan S, Dolman E, Lijnzaad P, Custers L, Begthel H, Kerstens HHD, Visser LL, Rookmaaker M, Verhaar M, Tytgat GAM, Kemmeren P, de Krijger RR, Al-Saadi R, Pritchard-Jones K, Kool M, Rios AC, van den Heuvel-Eibrink MM, Molenaar JJ, van Boxtel R, Holstege FCP, Clevers H, Drost J. Calandrini C, et al. Among authors: margaritis t. Nat Commun. 2020 Mar 11;11(1):1310. doi: 10.1038/s41467-020-15155-6. Nat Commun. 2020. PMID: 32161258 Free PMC article.
Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype.
Hanemaaijer ES, Margaritis T, Sanders K, Bos FL, Candelli T, Al-Saati H, van Noesel MM, Meyer-Wentrup FAG, van de Wetering M, Holstege FCP, Clevers H. Hanemaaijer ES, et al. Among authors: margaritis t. Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):e2022350118. doi: 10.1073/pnas.2022350118. Proc Natl Acad Sci U S A. 2021. PMID: 33500353 Free PMC article.
Tumor to normal single-cell mRNA comparisons reveal a pan-neuroblastoma cancer cell.
Kildisiute G, Kholosy WM, Young MD, Roberts K, Elmentaite R, van Hooff SR, Pacyna CN, Khabirova E, Piapi A, Thevanesan C, Bugallo-Blanco E, Burke C, Mamanova L, Keller KM, Langenberg-Ververgaert KPS, Lijnzaad P, Margaritis T, Holstege FCP, Tas ML, Wijnen MHWA, van Noesel MM, Del Valle I, Barone G, van der Linden R, Duncan C, Anderson J, Achermann JC, Haniffa M, Teichmann SA, Rampling D, Sebire NJ, He X, de Krijger RR, Barker RA, Meyer KB, Bayraktar O, Straathof K, Molenaar JJ, Behjati S. Kildisiute G, et al. Among authors: margaritis t. Sci Adv. 2021 Feb 5;7(6):eabd3311. doi: 10.1126/sciadv.abd3311. Print 2021 Feb. Sci Adv. 2021. PMID: 33547074 Free PMC article.
LGR6 marks nephron progenitor cells.
van Ineveld RL, Margaritis T, Kooiman BAP, Groenveld F, Ariese HCR, Lijnzaad P, Johnson HR, Korving J, Wehrens EJ, Holstege F, van Rheenen J, Drost J, Rios AC, Bos FL. van Ineveld RL, et al. Among authors: margaritis t. Dev Dyn. 2021 Nov;250(11):1568-1583. doi: 10.1002/dvdy.346. Epub 2021 May 6. Dev Dyn. 2021. PMID: 33848015 Free PMC article.
Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation.
He GW, Lin L, DeMartino J, Zheng X, Staliarova N, Dayton T, Begthel H, van de Wetering WJ, Bodewes E, van Zon J, Tans S, Lopez-Iglesias C, Peters PJ, Wu W, Kotlarz D, Klein C, Margaritis T, Holstege F, Clevers H. He GW, et al. Among authors: margaritis t. Cell Stem Cell. 2022 Sep 1;29(9):1333-1345.e6. doi: 10.1016/j.stem.2022.08.002. Epub 2022 Aug 23. Cell Stem Cell. 2022. PMID: 36002022 Free PMC article.
30 results