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Metalloprotease ADAM9 cleaves ephrin-B ligands and differentially regulates Wnt and mTOR signaling downstream of Akt kinase in colorectal cancer cells.
Chandrasekera P, Perfetto M, Lu C, Zhuo M, Bahudhanapati H, Li J, Chen WC, Kulkarni P, Christian L, Liu J, Yien YY, Yu C, Wei S. Chandrasekera P, et al. Among authors: perfetto m. J Biol Chem. 2022 Aug;298(8):102225. doi: 10.1016/j.jbc.2022.102225. Epub 2022 Jul 1. J Biol Chem. 2022. PMID: 35780836 Free PMC article.
The ubiquitous mitochondrial protein unfoldase CLPX regulates erythroid heme synthesis by control of iron utilization and heme synthesis enzyme activation and turnover.
Rondelli CM, Perfetto M, Danoff A, Bergonia H, Gillis S, O'Neill L, Jackson L, Nicolas G, Puy H, West R, Phillips JD, Yien YY. Rondelli CM, et al. Among authors: perfetto m. J Biol Chem. 2021 Aug;297(2):100972. doi: 10.1016/j.jbc.2021.100972. Epub 2021 Jul 16. J Biol Chem. 2021. PMID: 34280433 Free PMC article.