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Myotonic dystrophy type 1 embryonic stem cells show decreased myogenic potential, increased CpG methylation at the DMPK locus and RNA mis-splicing.
Franck S, Couvreu De Deckersberg E, Bubenik JL, Markouli C, Barbé L, Allemeersch J, Hilven P, Duqué G, Swanson MS, Gheldof A, Spits C, Sermon KD. Franck S, et al. Among authors: markouli c. Biol Open. 2022 Jan 15;11(1):bio058978. doi: 10.1242/bio.058978. Epub 2022 Jan 12. Biol Open. 2022. PMID: 35019138 Free PMC article.
Endogenous suppression of WNT signalling in human embryonic stem cells leads to low differentiation propensity towards definitive endoderm.
Dziedzicka D, Tewary M, Keller A, Tilleman L, Prochazka L, Östblom J, Couvreu De Deckersberg E, Markouli C, Franck S, Van Nieuwerburgh F, Spits C, Zandstra PW, Sermon K, Geens M. Dziedzicka D, et al. Among authors: markouli c. Sci Rep. 2021 Mar 17;11(1):6137. doi: 10.1038/s41598-021-85447-4. Sci Rep. 2021. PMID: 33731744 Free PMC article.
Random Mutagenesis, Clonal Events, and Embryonic or Somatic Origin Determine the mtDNA Variant Type and Load in Human Pluripotent Stem Cells.
Zambelli F, Mertens J, Dziedzicka D, Sterckx J, Markouli C, Keller A, Tropel P, Jung L, Viville S, Van de Velde H, Geens M, Seneca S, Sermon K, Spits C. Zambelli F, et al. Among authors: markouli c. Stem Cell Reports. 2018 Jul 10;11(1):102-114. doi: 10.1016/j.stemcr.2018.05.007. Epub 2018 Jun 14. Stem Cell Reports. 2018. PMID: 29910126 Free PMC article.