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Page 1
Brain glycogen serves as a critical glucosamine cache required for protein glycosylation.
Sun RC, Young LEA, Bruntz RC, Markussen KH, Zhou Z, Conroy LR, Hawkinson TR, Clarke HA, Stanback AE, Macedo JKA, Emanuelle S, Brewer MK, Rondon AL, Mestas A, Sanders WC, Mahalingan KK, Tang B, Chikwana VM, Segvich DM, Contreras CJ, Allenger EJ, Brainson CF, Johnson LA, Taylor RE, Armstrong DD, Shaffer R, Waechter CJ, Vander Kooi CW, DePaoli-Roach AA, Roach PJ, Hurley TD, Drake RR, Gentry MS. Sun RC, et al. Among authors: markussen kh. Cell Metab. 2021 Jul 6;33(7):1404-1417.e9. doi: 10.1016/j.cmet.2021.05.003. Epub 2021 May 26. Cell Metab. 2021. PMID: 34043942 Free PMC article.
Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease.
Andersen JV, Skotte NH, Christensen SK, Polli FS, Shabani M, Markussen KH, Haukedal H, Westi EW, Diaz-delCastillo M, Sun RC, Kohlmeier KA, Schousboe A, Gentry MS, Tanila H, Freude KK, Aldana BI, Mann M, Waagepetersen HS. Andersen JV, et al. Among authors: markussen kh. Cell Death Dis. 2021 Oct 16;12(11):954. doi: 10.1038/s41419-021-04237-y. Cell Death Dis. 2021. PMID: 34657143 Free PMC article.
In situ spatial glycomic imaging of mouse and human Alzheimer's disease brains.
Hawkinson TR, Clarke HA, Young LEA, Conroy LR, Markussen KH, Kerch KM, Johnson LA, Nelson PT, Wang C, Allison DB, Gentry MS, Sun RC. Hawkinson TR, et al. Among authors: markussen kh. Alzheimers Dement. 2022 Oct;18(10):1721-1735. doi: 10.1002/alz.12523. Epub 2021 Dec 15. Alzheimers Dement. 2022. PMID: 34908231 Free PMC article.
Two Diseases-One Preclinical Treatment Targeting Glycogen Synthesis.
Gentry MS, Markussen KH, Donohue KJ. Gentry MS, et al. Among authors: markussen kh. Neurotherapeutics. 2022 Apr;19(3):977-981. doi: 10.1007/s13311-022-01240-9. Epub 2022 Apr 22. Neurotherapeutics. 2022. PMID: 35460010 Free PMC article. No abstract available.
[No title available]
[No authors listed] [No authors listed] PMID: 35554495
Metabolic modulation of synaptic failure and thalamocortical hypersynchronization with preserved consciousness in Glut1 deficiency.
Rajasekaran K, Ma Q, Good LB, Kathote G, Jakkamsetti V, Liu P, Avila A, Primeaux S, Enciso Alva J, Markussen KH, Marin-Valencia I, Sirsi D, Hacker PMS, Gentry MS, Su J, Lu H, Pascual JM. Rajasekaran K, et al. Among authors: markussen kh. Sci Transl Med. 2022 Oct 5;14(665):eabn2956. doi: 10.1126/scitranslmed.abn2956. Epub 2022 Oct 5. Sci Transl Med. 2022. PMID: 36197967 Free PMC article.
In situ microwave fixation provides an instantaneous snapshot of the brain metabolome.
Juras JA, Webb MB, Young LEA, Markussen KH, Hawkinson TR, Buoncristiani MD, Bolton KE, Coburn PT, Williams MI, Sun LPY, Sanders WC, Bruntz RC, Conroy LR, Wang C, Gentry MS, Smith BN, Sun RC. Juras JA, et al. Among authors: markussen kh. Cell Rep Methods. 2023 Apr 18;3(4):100455. doi: 10.1016/j.crmeth.2023.100455. eCollection 2023 Apr 24. Cell Rep Methods. 2023. PMID: 37159672 Free PMC article.
Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis.
Conroy LR, Clarke HA, Allison DB, Valenca SS, Sun Q, Hawkinson TR, Young LEA, Ferreira JE, Hammonds AV, Dunne JB, McDonald RJ, Absher KJ, Dong BE, Bruntz RC, Markussen KH, Juras JA, Alilain WJ, Liu J, Gentry MS, Angel PM, Waters CM, Sun RC. Conroy LR, et al. Among authors: markussen kh. Nat Commun. 2023 May 13;14(1):2759. doi: 10.1038/s41467-023-38437-1. Nat Commun. 2023. PMID: 37179348 Free PMC article.
15 results