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Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response.
Rajsbaum R, Versteeg GA, Schmid S, Maestre AM, Belicha-Villanueva A, Martínez-Romero C, Patel JR, Morrison J, Pisanelli G, Miorin L, Laurent-Rolle M, Moulton HM, Stein DA, Fernandez-Sesma A, tenOever BR, García-Sastre A. Rajsbaum R, et al. Immunity. 2014 Jun 19;40(6):880-95. doi: 10.1016/j.immuni.2014.04.018. Epub 2014 May 29. Immunity. 2014. PMID: 24882218 Free PMC article.
Against the clock towards new Ebola virus therapies.
Martínez-Romero C, García-Sastre A. Martínez-Romero C, et al. Virus Res. 2015 Nov 2;209:4-10. doi: 10.1016/j.virusres.2015.05.025. Epub 2015 Jun 6. Virus Res. 2015. PMID: 26057711 Review.
Innate Immune Response to Influenza Virus at Single-Cell Resolution in Human Epithelial Cells Revealed Paracrine Induction of Interferon Lambda 1.
Ramos I, Smith G, Ruf-Zamojski F, Martínez-Romero C, Fribourg M, Carbajal EA, Hartmann BM, Nair VD, Marjanovic N, Monteagudo PL, DeJesus VA, Mutetwa T, Zamojski M, Tan GS, Jayaprakash C, Zaslavsky E, Albrecht RA, Sealfon SC, García-Sastre A, Fernandez-Sesma A. Ramos I, et al. J Virol. 2019 Sep 30;93(20):e00559-19. doi: 10.1128/JVI.00559-19. Print 2019 Oct 15. J Virol. 2019. PMID: 31375585 Free PMC article.
Pandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death.
Hartmann BM, Albrecht RA, Zaslavsky E, Nudelman G, Pincas H, Marjanovic N, Schotsaert M, Martínez-Romero C, Fenutria R, Ingram JP, Ramos I, Fernandez-Sesma A, Balachandran S, García-Sastre A, Sealfon SC. Hartmann BM, et al. Nat Commun. 2017 Dec 5;8(1):1931. doi: 10.1038/s41467-017-02035-9. Nat Commun. 2017. PMID: 29203926 Free PMC article.
Viral Fitness Landscapes in Diverse Host Species Reveal Multiple Evolutionary Lines for the NS1 Gene of Influenza A Viruses.
Muñoz-Moreno R, Martínez-Romero C, Blanco-Melo D, Forst CV, Nachbagauer R, Benitez AA, Mena I, Aslam S, Balasubramaniam V, Lee I, Panis M, Ayllón J, Sachs D, Park MS, Krammer F, tenOever BR, García-Sastre A. Muñoz-Moreno R, et al. Cell Rep. 2019 Dec 17;29(12):3997-4009.e5. doi: 10.1016/j.celrep.2019.11.070. Cell Rep. 2019. PMID: 31851929 Free PMC article.
Antiviral Role of IFITM Proteins in African Swine Fever Virus Infection.
Muñoz-Moreno R, Cuesta-Geijo MÁ, Martínez-Romero C, Barrado-Gil L, Galindo I, García-Sastre A, Alonso C. Muñoz-Moreno R, et al. PLoS One. 2016 Apr 26;11(4):e0154366. doi: 10.1371/journal.pone.0154366. eCollection 2016. PLoS One. 2016. PMID: 27116236 Free PMC article.
Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A.
White KM, Rosales R, Yildiz S, Kehrer T, Miorin L, Moreno E, Jangra S, Uccellini MB, Rathnasinghe R, Coughlan L, Martinez-Romero C, Batra J, Rojc A, Bouhaddou M, Fabius JM, Obernier K, Dejosez M, Guillén MJ, Losada A, Avilés P, Schotsaert M, Zwaka T, Vignuzzi M, Shokat KM, Krogan NJ, García-Sastre A. White KM, et al. Among authors: martinez romero c. Science. 2021 Feb 26;371(6532):926-931. doi: 10.1126/science.abf4058. Epub 2021 Jan 25. Science. 2021. PMID: 33495306 Free PMC article.
31 results