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Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging.
Cabral-Miranda F, Tamburini G, Martinez G, Ardiles AO, Medinas DB, Gerakis Y, Hung MD, Vidal R, Fuentealba M, Miedema T, Duran-Aniotz C, Diaz J, Ibaceta-Gonzalez C, Sabusap CM, Bermedo-Garcia F, Mujica P, Adamson S, Vitangcol K, Huerta H, Zhang X, Nakamura T, Sardi SP, Lipton SA, Kennedy BK, Henriquez JP, Cárdenas JC, Plate L, Palacios AG, Hetz C. Cabral-Miranda F, et al. Among authors: martinez g. EMBO J. 2022 Nov 17;41(22):e111952. doi: 10.15252/embj.2022111952. Epub 2022 Oct 31. EMBO J. 2022. PMID: 36314651 Free PMC article.
TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis.
Rojas-Rivera D, Armisén R, Colombo A, Martínez G, Eguiguren AL, Díaz A, Kiviluoto S, Rodríguez D, Patron M, Rizzuto R, Bultynck G, Concha ML, Sierralta J, Stutzin A, Hetz C. Rojas-Rivera D, et al. Among authors: martinez g. Cell Death Differ. 2012 Jun;19(6):1013-26. doi: 10.1038/cdd.2011.189. Epub 2012 Jan 13. Cell Death Differ. 2012. PMID: 22240901 Free PMC article.
Cell-nonautonomous control of the UPR.
Martínez G, Hetz C. Martínez G, et al. EMBO Rep. 2012 Sep;13(9):767-8. doi: 10.1038/embor.2012.117. Epub 2012 Aug 7. EMBO Rep. 2012. PMID: 22868667 Free PMC article. No abstract available.
Control of systemic proteostasis by the nervous system.
Mardones P, Martínez G, Hetz C. Mardones P, et al. Among authors: martinez g. Trends Cell Biol. 2015 Jan;25(1):1-10. doi: 10.1016/j.tcb.2014.08.001. Epub 2014 Aug 28. Trends Cell Biol. 2015. PMID: 25174273 Review.
Regulation of Memory Formation by the Transcription Factor XBP1.
Martínez G, Vidal RL, Mardones P, Serrano FG, Ardiles AO, Wirth C, Valdés P, Thielen P, Schneider BL, Kerr B, Valdés JL, Palacios AG, Inestrosa NC, Glimcher LH, Hetz C. Martínez G, et al. Cell Rep. 2016 Feb 16;14(6):1382-1394. doi: 10.1016/j.celrep.2016.01.028. Epub 2016 Feb 4. Cell Rep. 2016. PMID: 26854229 Free article.
Gene therapy to target ER stress in brain diseases.
Valenzuela V, Martínez G, Duran-Aniotz C, Hetz C. Valenzuela V, et al. Among authors: martinez g. Brain Res. 2016 Oct 1;1648(Pt B):561-570. doi: 10.1016/j.brainres.2016.04.064. Epub 2016 Apr 27. Brain Res. 2016. PMID: 27131987 Review.
2,173 results