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Bisindolylpyrrole triggers transient mitochondrial permeability transitions to cause apoptosis in a VDAC1/2 and cyclophilin D-dependent manner via the ANT-associated pore.
Sci Rep. 2020 Oct 12;10(1):16751. doi: 10.1038/s41598-020-73667-z.
Sci Rep. 2020.
PMID: 33046783
Free PMC article.
The yeast mitochondrial permeability transition is regulated by reactive oxygen species, endogenous Ca2+ and Cpr3, mediating cell death.
Kamei Y, Koushi M, Aoyama Y, Asakai R.
Kamei Y, et al. Among authors: koushi m.
Biochim Biophys Acta Bioenerg. 2018 Dec;1859(12):1313-1326. doi: 10.1016/j.bbabio.2018.07.004. Epub 2018 Jul 20.
Biochim Biophys Acta Bioenerg. 2018.
PMID: 30031690
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Bisindolylpyrrole Induces a Cpr3- and Porin1/2-Dependent Transition in Yeast Mitochondrial Permeability in a Low Conductance State via the AACs-Associated Pore.
Koushi M, Asakai R.
Koushi M, et al.
Int J Mol Sci. 2021 Jan 26;22(3):1212. doi: 10.3390/ijms22031212.
Int J Mol Sci. 2021.
PMID: 33530556
Free PMC article.
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