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Membrane binding, internalization, and sorting of alpha-synuclein in the cell.
Masaracchia C, Hnida M, Gerhardt E, Lopes da Fonseca T, Villar-Pique A, Branco T, Stahlberg MA, Dean C, Fernández CO, Milosevic I, Outeiro TF. Masaracchia C, et al. Acta Neuropathol Commun. 2018 Aug 14;6(1):79. doi: 10.1186/s40478-018-0578-1. Acta Neuropathol Commun. 2018. PMID: 30107856 Free PMC article.
Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity.
Villar-Piqué A, Lopes da Fonseca T, Sant'Anna R, Szegö ÉM, Fonseca-Ornelas L, Pinho R, Carija A, Gerhardt E, Masaracchia C, Abad Gonzalez E, Rossetti G, Carloni P, Fernández CO, Foguel D, Milosevic I, Zweckstetter M, Ventura S, Outeiro TF. Villar-Piqué A, et al. Among authors: masaracchia c. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6506-E6515. doi: 10.1073/pnas.1606791113. Epub 2016 Oct 5. Proc Natl Acad Sci U S A. 2016. PMID: 27708160 Free PMC article.
Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding.
Chiang AN, Liang M, Dominguez-Meijide A, Masaracchia C, Goeckeler-Fried JL, Mazzone CS, Newhouse DW, Kendsersky NM, Yates ME, Manos-Turvey A, Needham PG, Outeiro TF, Wipf P, Brodsky JL. Chiang AN, et al. Among authors: masaracchia c. Bioorg Med Chem. 2019 Jan 1;27(1):79-91. doi: 10.1016/j.bmc.2018.11.011. Epub 2018 Nov 15. Bioorg Med Chem. 2019. PMID: 30528127 Free PMC article.
High-Molecular-Weight Paired Helical Filaments from Alzheimer Brain Induces Seeding of Wild-Type Mouse Tau into an Argyrophilic 4R Tau Pathology in Vivo.
Audouard E, Houben S, Masaracchia C, Yilmaz Z, Suain V, Authelet M, De Decker R, Buée L, Boom A, Leroy K, Ando K, Brion JP. Audouard E, et al. Among authors: masaracchia c. Am J Pathol. 2016 Oct;186(10):2709-22. doi: 10.1016/j.ajpath.2016.06.008. Epub 2016 Aug 3. Am J Pathol. 2016. PMID: 27497324 Free article.