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PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis.
Dickey AS, Sanchez DN, Arreola M, Sampat KR, Fan W, Arbez N, Akimov S, Van Kanegan MJ, Ohnishi K, Gilmore-Hall SK, Flores AL, Nguyen JM, Lomas N, Hsu CL, Lo DC, Ross CA, Masliah E, Evans RM, La Spada AR. Dickey AS, et al. Among authors: masliah e. Sci Transl Med. 2017 Dec 6;9(419):eaal2332. doi: 10.1126/scitranslmed.aal2332. Sci Transl Med. 2017. PMID: 29212711 Free PMC article.
Dual effects of β-synuclein on the pathogenesis of Parkinson disease.
Sekigawa A, Sekiyama K, Fujita M, Takamatsu Y, La Spada AR, Masliah E, Hashimoto M. Sekigawa A, et al. Among authors: masliah e. Ann Neurol. 2013 Aug;74(2):306. doi: 10.1002/ana.23936. Epub 2013 Jul 8. Ann Neurol. 2013. PMID: 23836414 No abstract available.
Disease-Modifying Effect of Adiponectin in Model of α-Synucleinopathies.
Sekiyama K, Waragai M, Akatsu H, Sugama S, Takenouchi T, Takamatsu Y, Fujita M, Sekigawa A, Rockenstein E, Inoue S, La Spada AR, Masliah E, Hashimoto M. Sekiyama K, et al. Among authors: masliah e. Ann Clin Transl Neurol. 2014 Jul 3;1(7):479-489. doi: 10.1002/acn3.77. Ann Clin Transl Neurol. 2014. PMID: 25126588 Free PMC article.
Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy.
Dubinsky AN, Dastidar SG, Hsu CL, Zahra R, Djakovic SN, Duarte S, Esau CC, Spencer B, Ashe TD, Fischer KM, MacKenna DA, Sopher BL, Masliah E, Gaasterland T, Chau BN, Pereira de Almeida L, Morrison BE, La Spada AR. Dubinsky AN, et al. Among authors: masliah e. Cell Metab. 2014 Oct 7;20(4):626-38. doi: 10.1016/j.cmet.2014.09.001. Cell Metab. 2014. PMID: 25295787 Free PMC article.
PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically.
Dickey AS, Pineda VV, Tsunemi T, Liu PP, Miranda HC, Gilmore-Hall SK, Lomas N, Sampat KR, Buttgereit A, Torres MJ, Flores AL, Arreola M, Arbez N, Akimov SS, Gaasterland T, Lazarowski ER, Ross CA, Yeo GW, Sopher BL, Magnuson GK, Pinkerton AB, Masliah E, La Spada AR. Dickey AS, et al. Among authors: masliah e. Nat Med. 2016 Jan;22(1):37-45. doi: 10.1038/nm.4003. Epub 2015 Dec 7. Nat Med. 2016. PMID: 26642438 Free PMC article.
LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies.
Kim C, Beilina A, Smith N, Li Y, Kim M, Kumaran R, Kaganovich A, Mamais A, Adame A, Iba M, Kwon S, Lee WJ, Shin SJ, Rissman RA, You S, Lee SJ, Singleton AB, Cookson MR, Masliah E. Kim C, et al. Among authors: masliah e. Sci Transl Med. 2020 Oct 14;12(565):eaay0399. doi: 10.1126/scitranslmed.aay0399. Sci Transl Med. 2020. PMID: 33055242 Free PMC article.
1,059 results