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Programmed anuclear cell death delimits platelet life span.
Mason KD, Carpinelli MR, Fletcher JI, Collinge JE, Hilton AA, Ellis S, Kelly PN, Ekert PG, Metcalf D, Roberts AW, Huang DC, Kile BT. Mason KD, et al. Cell. 2007 Mar 23;128(6):1173-86. doi: 10.1016/j.cell.2007.01.037. Cell. 2007. PMID: 17382885 Free article.
Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets.
Josefsson EC, James C, Henley KJ, Debrincat MA, Rogers KL, Dowling MR, White MJ, Kruse EA, Lane RM, Ellis S, Nurden P, Mason KD, O'Reilly LA, Roberts AW, Metcalf D, Huang DC, Kile BT. Josefsson EC, et al. Among authors: mason kd. J Exp Med. 2011 Sep 26;208(10):2017-31. doi: 10.1084/jem.20110750. Epub 2011 Sep 12. J Exp Med. 2011. PMID: 21911424 Free PMC article.
Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function.
Schoenwaelder SM, Yuan Y, Josefsson EC, White MJ, Yao Y, Mason KD, O'Reilly LA, Henley KJ, Ono A, Hsiao S, Willcox A, Roberts AW, Huang DC, Salem HH, Kile BT, Jackson SP. Schoenwaelder SM, et al. Among authors: mason kd. Blood. 2009 Jul 16;114(3):663-6. doi: 10.1182/blood-2009-01-200345. Epub 2009 Apr 22. Blood. 2009. PMID: 19387006 Free article.
Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets.
Schoenwaelder SM, Jarman KE, Gardiner EE, Hua M, Qiao J, White MJ, Josefsson EC, Alwis I, Ono A, Willcox A, Andrews RK, Mason KD, Salem HH, Huang DC, Kile BT, Roberts AW, Jackson SP. Schoenwaelder SM, et al. Among authors: mason kd. Blood. 2011 Aug 11;118(6):1663-74. doi: 10.1182/blood-2011-04-347849. Epub 2011 Jun 14. Blood. 2011. PMID: 21673344 Free article.
Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis.
Speir M, Lawlor KE, Glaser SP, Abraham G, Chow S, Vogrin A, Schulze KE, Schuelein R, O'Reilly LA, Mason K, Hartland EL, Lithgow T, Strasser A, Lessene G, Huang DC, Vince JE, Naderer T. Speir M, et al. Nat Microbiol. 2016 Feb 24;1:15034. doi: 10.1038/nmicrobiol.2015.34. Nat Microbiol. 2016. PMID: 27572165
37 results