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Membrane curvature bends the laws of physics and chemistry.
Iversen L, Mathiasen S, Larsen JB, Stamou D. Iversen L, et al. Among authors: mathiasen s. Nat Chem Biol. 2015 Nov;11(11):822-5. doi: 10.1038/nchembio.1941. Nat Chem Biol. 2015. PMID: 26485070 No abstract available.
Single-molecule analysis of ligand efficacy in β2AR-G-protein activation.
Gregorio GG, Masureel M, Hilger D, Terry DS, Juette M, Zhao H, Zhou Z, Perez-Aguilar JM, Hauge M, Mathiasen S, Javitch JA, Weinstein H, Kobilka BK, Blanchard SC. Gregorio GG, et al. Among authors: mathiasen s. Nature. 2017 Jul 6;547(7661):68-73. doi: 10.1038/nature22354. Epub 2017 Jun 7. Nature. 2017. PMID: 28607487 Free PMC article.
Single-molecule FRET imaging of GPCR dimers in living cells.
Asher WB, Geggier P, Holsey MD, Gilmore GT, Pati AK, Meszaros J, Terry DS, Mathiasen S, Kaliszewski MJ, McCauley MD, Govindaraju A, Zhou Z, Harikumar KG, Jaqaman K, Miller LJ, Smith AW, Blanchard SC, Javitch JA. Asher WB, et al. Among authors: mathiasen s. Nat Methods. 2021 Apr;18(4):397-405. doi: 10.1038/s41592-021-01081-y. Epub 2021 Mar 8. Nat Methods. 2021. PMID: 33686301 Free PMC article.
Agonist-induced formation of unproductive receptor-G12 complexes.
Okashah N, Wright SC, Kawakami K, Mathiasen S, Zhou J, Lu S, Javitch JA, Inoue A, Bouvier M, Lambert NA. Okashah N, et al. Among authors: mathiasen s. Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21723-21730. doi: 10.1073/pnas.2003787117. Epub 2020 Aug 17. Proc Natl Acad Sci U S A. 2020. PMID: 32817560 Free PMC article.
G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3.
Mathiasen S, Palmisano T, Perry NA, Stoveken HM, Vizurraga A, McEwen DP, Okashah N, Langenhan T, Inoue A, Lambert NA, Tall GG, Javitch JA. Mathiasen S, et al. Nat Chem Biol. 2020 Dec;16(12):1343-1350. doi: 10.1038/s41589-020-0617-7. Epub 2020 Aug 10. Nat Chem Biol. 2020. PMID: 32778842 Free PMC article.
17 results