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Page 1
The quest to slow ageing through drug discovery.
Partridge L, Fuentealba M, Kennedy BK. Partridge L, et al. Among authors: fuentealba m. Nat Rev Drug Discov. 2020 Aug;19(8):513-532. doi: 10.1038/s41573-020-0067-7. Epub 2020 May 28. Nat Rev Drug Discov. 2020. PMID: 32467649 Review.
Identifying Potential Ageing-Modulating Drugs In Silico.
Dönertaş HM, Fuentealba M, Partridge L, Thornton JM. Dönertaş HM, et al. Among authors: fuentealba m. Trends Endocrinol Metab. 2019 Feb;30(2):118-131. doi: 10.1016/j.tem.2018.11.005. Epub 2018 Dec 20. Trends Endocrinol Metab. 2019. PMID: 30581056 Free PMC article. Review.
The unfolded protein response transcription factor XBP1s ameliorates Alzheimer's disease by improving synaptic function and proteostasis.
Duran-Aniotz C, Poblete N, Rivera-Krstulovic C, Ardiles ÁO, Díaz-Hung ML, Tamburini G, Sabusap CMP, Gerakis Y, Cabral-Miranda F, Diaz J, Fuentealba M, Arriagada D, Muñoz E, Espinoza S, Martinez G, Quiroz G, Sardi P, Medinas DB, Contreras D, Piña R, Lourenco MV, Ribeiro FC, Ferreira ST, Rozas C, Morales B, Plate L, Gonzalez-Billault C, Palacios AG, Hetz C. Duran-Aniotz C, et al. Among authors: fuentealba m. Mol Ther. 2023 Jul 5;31(7):2240-2256. doi: 10.1016/j.ymthe.2023.03.028. Epub 2023 Apr 4. Mol Ther. 2023. PMID: 37016577
Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging.
Cabral-Miranda F, Tamburini G, Martinez G, Ardiles AO, Medinas DB, Gerakis Y, Hung MD, Vidal R, Fuentealba M, Miedema T, Duran-Aniotz C, Diaz J, Ibaceta-Gonzalez C, Sabusap CM, Bermedo-Garcia F, Mujica P, Adamson S, Vitangcol K, Huerta H, Zhang X, Nakamura T, Sardi SP, Lipton SA, Kennedy BK, Henriquez JP, Cárdenas JC, Plate L, Palacios AG, Hetz C. Cabral-Miranda F, et al. Among authors: fuentealba m. EMBO J. 2022 Nov 17;41(22):e111952. doi: 10.15252/embj.2022111952. Epub 2022 Oct 31. EMBO J. 2022. PMID: 36314651 Free PMC article.
The neuronal receptor tyrosine kinase Alk is a target for longevity.
Woodling NS, Aleyakpo B, Dyson MC, Minkley LJ, Rajasingam A, Dobson AJ, Leung KHC, Pomposova S, Fuentealba M, Alic N, Partridge L. Woodling NS, et al. Among authors: fuentealba m. Aging Cell. 2020 May;19(5):e13137. doi: 10.1111/acel.13137. Epub 2020 Apr 15. Aging Cell. 2020. PMID: 32291952 Free PMC article.
14 results