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Molecular characterization of binding subcomponents of Clostridium botulinum type C progenitor toxin for intestinal epithelial cells and erythrocytes.
Fujinaga Y, Inoue K, Watarai S, Sakaguchi Y, Arimitsu H, Lee JC, Jin Y, Matsumura T, Kabumoto Y, Watanabe T, Ohyama T, Nishikawa A, Oguma K. Fujinaga Y, et al. Among authors: matsumura t. Microbiology (Reading). 2004 May;150(Pt 5):1529-1538. doi: 10.1099/mic.0.26805-0. Microbiology (Reading). 2004. PMID: 15133114 Free article.
A novel function of botulinum toxin-associated proteins: HA proteins disrupt intestinal epithelial barrier to increase toxin absorption.
Fujinaga Y, Matsumura T, Jin Y, Takegahara Y, Sugawara Y. Fujinaga Y, et al. Among authors: matsumura t. Toxicon. 2009 Oct;54(5):583-6. doi: 10.1016/j.toxicon.2008.11.014. Epub 2008 Dec 6. Toxicon. 2009. PMID: 19073205
We found that hemagglutinin (HA) proteins of type B BoNT complex play an important role in the intestinal absorption of BoNT, disrupting the paracellular barrier of intestinal epithelium, which facilitates transepithelial delivery of BoNT both in vitro and in vivo (Matsumura …
We found that hemagglutinin (HA) proteins of type B BoNT complex play an important role in the intestinal absorption of BoNT, disrupting the …
Crystallization and preliminary crystallographic studies of the HA3 subcomponent of the type B botulinum neurotoxin complex.
Nishimura K, Kitadokoro K, Takegahara Y, Sugawara Y, Matsumura T, Karatani H, Fujinaga Y. Nishimura K, et al. Among authors: matsumura t. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt 10):1244-6. doi: 10.1107/S1744309111027412. Epub 2011 Sep 29. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011. PMID: 22102038 Free PMC article.
Uptake of botulinum neurotoxin in the intestine.
Fujinaga Y, Sugawara Y, Matsumura T. Fujinaga Y, et al. Among authors: matsumura t. Curr Top Microbiol Immunol. 2013;364:45-59. doi: 10.1007/978-3-642-33570-9_3. Curr Top Microbiol Immunol. 2013. PMID: 23239348 Review.
2,156 results