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RNAi-mediated gene silencing in non-human primates.
Zimmermann TS, Lee AC, Akinc A, Bramlage B, Bumcrot D, Fedoruk MN, Harborth J, Heyes JA, Jeffs LB, John M, Judge AD, Lam K, McClintock K, Nechev LV, Palmer LR, Racie T, Röhl I, Seiffert S, Shanmugam S, Sood V, Soutschek J, Toudjarska I, Wheat AJ, Yaworski E, Zedalis W, Koteliansky V, Manoharan M, Vornlocher HP, MacLachlan I. Zimmermann TS, et al. Among authors: mcclintock k. Nature. 2006 May 4;441(7089):111-4. doi: 10.1038/nature04688. Epub 2006 Mar 26. Nature. 2006. PMID: 16565705
Postexposure protection of guinea pigs against a lethal ebola virus challenge is conferred by RNA interference.
Geisbert TW, Hensley LE, Kagan E, Yu EZ, Geisbert JB, Daddario-DiCaprio K, Fritz EA, Jahrling PB, McClintock K, Phelps JR, Lee AC, Judge A, Jeffs LB, MacLachlan I. Geisbert TW, et al. Among authors: mcclintock k. J Infect Dis. 2006 Jun 15;193(12):1650-7. doi: 10.1086/504267. Epub 2006 May 10. J Infect Dis. 2006. PMID: 16703508 Free PMC article.
2'-O-methyl-modified RNAs act as TLR7 antagonists.
Robbins M, Judge A, Liang L, McClintock K, Yaworski E, MacLachlan I. Robbins M, et al. Among authors: mcclintock k. Mol Ther. 2007 Sep;15(9):1663-9. doi: 10.1038/sj.mt.6300240. Epub 2007 Jun 19. Mol Ther. 2007. PMID: 17579574 Free article.
Ligand conjugate SAR and enhanced delivery in NHP.
Holland RJ, Lam K, Ye X, Martin AD, Wood MC, Palmer L, Fraser D, McClintock K, Majeski S, Jarosz A, Lee ACH, Thi EP, Judge A, Heyes J. Holland RJ, et al. Among authors: mcclintock k. Mol Ther. 2021 Oct 6;29(10):2910-2919. doi: 10.1016/j.ymthe.2021.06.002. Epub 2021 Jun 4. Mol Ther. 2021. PMID: 34091052 Free PMC article.
Preclinical Profile of AB-423, an Inhibitor of Hepatitis B Virus Pregenomic RNA Encapsidation.
Mani N, Cole AG, Phelps JR, Ardzinski A, Cobarrubias KD, Cuconati A, Dorsey BD, Evangelista E, Fan K, Guo F, Guo H, Guo JT, Harasym TO, Kadhim S, Kultgen SG, Lee ACH, Li AHL, Long Q, Majeski SA, Mao R, McClintock KD, Reid SP, Rijnbrand R, Snead NM, Micolochick Steuer HM, Stever K, Tang S, Wang X, Zhao Q, Sofia MJ. Mani N, et al. Among authors: mcclintock kd. Antimicrob Agents Chemother. 2018 May 25;62(6):e00082-18. doi: 10.1128/AAC.00082-18. Print 2018 Jun. Antimicrob Agents Chemother. 2018. PMID: 29555628 Free PMC article.
33 results