McKerrow JH - Search Results

1

High-throughput analysis of an RNAi library identifies novel kinase targets in Trypanosoma brucei.

Mackey ZB, Koupparis K, Nishino M, McKerrow JH. Mackey ZB, et al. Among authors: mckerrow jh. Chem Biol Drug Des. 2011 Sep;78(3):454-63. doi: 10.1111/j.1747-0285.2011.01156.x. Epub 2011 Jul 14. Chem Biol Drug Des. 2011. PMID: 21668652 Free PMC article.

2

A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei.

Mackey ZB, O'Brien TC, Greenbaum DC, Blank RB, McKerrow JH. Mackey ZB, et al. Among authors: mckerrow jh. J Biol Chem. 2004 Nov 12;279(46):48426-33. doi: 10.1074/jbc.M402470200. Epub 2004 Aug 23. J Biol Chem. 2004. PMID: 15326171 Free article.

3

Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei.

Mackey ZB, Baca AM, Mallari JP, Apsel B, Shelat A, Hansell EJ, Chiang PK, Wolff B, Guy KR, Williams J, McKerrow JH. Mackey ZB, et al. Among authors: mckerrow jh. Chem Biol Drug Des. 2006 May;67(5):355-63. doi: 10.1111/j.1747-0285.2006.00389.x. Chem Biol Drug Des. 2006. PMID: 16784460

4

RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model.

Abdulla MH, O'Brien T, Mackey ZB, Sajid M, Grab DJ, McKerrow JH. Abdulla MH, et al. Among authors: mckerrow jh. PLoS Negl Trop Dis. 2008 Sep 24;2(9):e298. doi: 10.1371/journal.pntd.0000298. PLoS Negl Trop Dis. 2008. PMID: 18820745 Free PMC article.

5

Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei [corrected].

Nishino M, Choy JW, Gushwa NN, Oses-Prieto JA, Koupparis K, Burlingame AL, Renslo AR, McKerrow JH, Taunton J. Nishino M, et al. Among authors: mckerrow jh. Elife. 2013 Jul 9;2:e00712. doi: 10.7554/eLife.00712. Elife. 2013. PMID: 23853713 Free PMC article.

6

Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.

Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K. Greenbaum DC, et al. Among authors: mckerrow jh. J Med Chem. 2004 Jun 3;47(12):3212-9. doi: 10.1021/jm030549j. J Med Chem. 2004. PMID: 15163200

7

A parasite cysteine protease is key to host protein degradation and iron acquisition.

O'Brien TC, Mackey ZB, Fetter RD, Choe Y, O'Donoghue AJ, Zhou M, Craik CS, Caffrey CR, McKerrow JH. O'Brien TC, et al. Among authors: mckerrow jh. J Biol Chem. 2008 Oct 24;283(43):28934-43. doi: 10.1074/jbc.M805824200. Epub 2008 Aug 13. J Biol Chem. 2008. PMID: 18701454 Free PMC article.

8

Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit.

Chen CK, Doyle PS, Yermalitskaya LV, Mackey ZB, Ang KK, McKerrow JH, Podust LM. Chen CK, et al. Among authors: mckerrow jh. PLoS Negl Trop Dis. 2009;3(2):e372. doi: 10.1371/journal.pntd.0000372. Epub 2009 Feb 3. PLoS Negl Trop Dis. 2009. PMID: 19190730 Free PMC article.

9

Mining a cathepsin inhibitor library for new antiparasitic drug leads.

Ang KK, Ratnam J, Gut J, Legac J, Hansell E, Mackey ZB, Skrzypczynska KM, Debnath A, Engel JC, Rosenthal PJ, McKerrow JH, Arkin MR, Renslo AR. Ang KK, et al. Among authors: mckerrow jh. PLoS Negl Trop Dis. 2011 May 3;5(5):e1023. doi: 10.1371/journal.pntd.0001023. PLoS Negl Trop Dis. 2011. PMID: 21572521 Free PMC article.

10

A global comparison of the human and T. brucei degradomes gives insights about possible parasite drug targets.

Mashiyama ST, Koupparis K, Caffrey CR, McKerrow JH, Babbitt PC. Mashiyama ST, et al. Among authors: mckerrow jh. PLoS Negl Trop Dis. 2012;6(12):e1942. doi: 10.1371/journal.pntd.0001942. Epub 2012 Dec 6. PLoS Negl Trop Dis. 2012. PMID: 23236535 Free PMC article.

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