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Page 1
Somatic gene mutations expose cytoplasmic DNA to co-opt the cGAS/STING/NLRP3 axis in myelodysplastic syndromes.
JCI Insight. 2022 Aug 8;7(15):e159430. doi: 10.1172/jci.insight.159430.
JCI Insight. 2022.
PMID: 35788117
Free PMC article.
Oxidized Mitochondrial DNA Engages TLR9 to Activate the NLRP3 Inflammasome in Myelodysplastic Syndromes.
Ward GA, Dalton RP 3rd, Meyer BS, McLemore AF, Aldrich AL, Lam NB, Onimus AH, Vincelette ND, Trinh TL, Chen X, Calescibetta AR, Christiansen SM, Hou HA, Johnson JO, Wright KL, Padron E, Eksioglu EA, List AF.
Ward GA, et al. Among authors: mclemore af.
Int J Mol Sci. 2023 Feb 15;24(4):3896. doi: 10.3390/ijms24043896.
Int J Mol Sci. 2023.
PMID: 36835307
Free PMC article.
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Dual pyroptotic biomarkers predict erythroid response in lower-risk non-del(5q) myelodysplastic syndromes treated with lenalidomide and recombinant erythropoietin.
Wang C, McGraw KL, McLemore AF, Komrokji R, Basiorka AA, Al Ali N, Lancet JE, Padron E, Kosmider O, Fontenay M, Fenaux P, List AF, Sallman DA.
Wang C, et al. Among authors: mclemore af.
Haematologica. 2022 Mar 1;107(3):737-739. doi: 10.3324/haematol.2021.278855.
Haematologica. 2022.
PMID: 34320786
Free PMC article.
No abstract available.
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TP53 mutations in myelodysplastic syndromes and secondary AML confer an immunosuppressive phenotype.
Sallman DA, McLemore AF, Aldrich AL, Komrokji RS, McGraw KL, Dhawan A, Geyer S, Hou HA, Eksioglu EA, Sullivan A, Warren S, MacBeth KJ, Meggendorfer M, Haferlach T, Boettcher S, Ebert BL, Al Ali NH, Lancet JE, Cleveland JL, Padron E, List AF.
Sallman DA, et al. Among authors: mclemore af.
Blood. 2020 Dec 10;136(24):2812-2823. doi: 10.1182/blood.2020006158.
Blood. 2020.
PMID: 32730593
Free PMC article.
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Oxidized mitochondrial DNA released after inflammasome activation is a disease biomarker for myelodysplastic syndromes.
Ward GA, McGraw KL, Abbas-Aghababazadeh F, Meyer BS, McLemore AF, Vincelette ND, Lam NB, Aldrich AL, Al Ali NH, Padron E, Pinilla-Ibarz J, Masala E, Santini V, Kosmider O, Fontenay M, Fenaux P, Johnson J, Fridley BL, List AF.
Ward GA, et al. Among authors: mclemore af.
Blood Adv. 2021 Apr 27;5(8):2216-2228. doi: 10.1182/bloodadvances.2020003475.
Blood Adv. 2021.
PMID: 33890980
Free PMC article.
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Pyroptosis Markers in Human Primary Specimens: Quantification of Intracellular ASC Specks by Imaging Flow Cytometry and Extracellular Oxidized Mitochondrial by ELISA.
McLemore AF, Lage SL, Dominical VM, Rodrigues MA, McGraw KL.
McLemore AF, et al.
Methods Mol Biol. 2023;2641:81-100. doi: 10.1007/978-1-0716-3040-2_7.
Methods Mol Biol. 2023.
PMID: 37074643
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Assessment of ASC specks as a putative biomarker of pyroptosis in myelodysplastic syndromes: an observational cohort study.
Basiorka AA, McGraw KL, Abbas-Aghababazadeh F, McLemore AF, Vincelette ND, Ward GA, Eksioglu EA, Sallman DA, Ali NA, Padron E, Pinilla-Ibarz J, Komrokji R, Masala E, Santini V, Kosmider O, Fontenay M, Fenaux P, Sokol L, Wei S, Fridley B, List AF.
Basiorka AA, et al. Among authors: mclemore af.
Lancet Haematol. 2018 Sep;5(9):e393-e402. doi: 10.1016/S2352-3026(18)30109-1. Epub 2018 Jul 30.
Lancet Haematol. 2018.
PMID: 30072146
Free PMC article.
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