Constrained models of evolution lead to improved prediction of functional linkage from correlated gain and loss of genes.
Barker D, Meade A, Pagel M.
Barker D, et al. Among authors: meade a.
Bioinformatics. 2007 Jan 1;23(1):14-20. doi: 10.1093/bioinformatics/btl558. Epub 2006 Nov 7.
Bioinformatics. 2007.
PMID: 17090580
We further examine the effect of constraining the ML model by fixing the rate of gene gain at a low value, rather than estimating it from the data. RESULTS: We detect correlated evolution among a test set of pairs of yeast (Saccharomyces cerevisiae) genes, with a …
We further examine the effect of constraining the ML model by fixing the rate of gene gain at a low value, rather than estimating it …