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Boosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects.
Han K, Singh K, Meadows AM, Sharma R, Hassanzadeh S, Wu J, Goss-Holmes H, Huffstutler RD, Teague HL, Mehta NN, Griffin JL, Tian R, Traba J, Sack MN. Han K, et al. Among authors: meadows am. Cell Rep Med. 2023 Sep 19;4(9):101157. doi: 10.1016/j.xcrm.2023.101157. Epub 2023 Aug 15. Cell Rep Med. 2023. PMID: 37586364 Free PMC article.
Propionate functions as a feeding state-dependent regulatory metabolite to counter proinflammatory signaling linked to nutrient load and obesity.
Han K, Meadows AM, Rodman MJ, Russo AC, Sharma R, Singh K, Hassanzadeh S, Dagur PK, Huffstutler RD, Krause FN, Griffin JL, Baumer Y, Powell-Wiley TM, Sack MN. Han K, et al. Among authors: meadows am. J Leukoc Biol. 2024 Mar 29;115(4):738-749. doi: 10.1093/jleuko/qiae006. J Leukoc Biol. 2024. PMID: 38207130 Free PMC article.
Protein phosphatase 2A regulatory subunit B56α limits phosphatase activity in the heart.
Little SC, Curran J, Makara MA, Kline CF, Ho HT, Xu Z, Wu X, Polina I, Musa H, Meadows AM, Carnes CA, Biesiadecki BJ, Davis JP, Weisleder N, Györke S, Wehrens XH, Hund TJ, Mohler PJ. Little SC, et al. Among authors: meadows am. Sci Signal. 2015 Jul 21;8(386):ra72. doi: 10.1126/scisignal.aaa5876. Sci Signal. 2015. PMID: 26198358 Free PMC article.