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XLF acts as a flexible connector during non-homologous end joining.
Carney SM, Moreno AT, Piatt SC, Cisneros-Aguirre M, Lopezcolorado FW, Stark JM, Loparo JJ. Carney SM, et al. Among authors: cisneros aguirre m. Elife. 2020 Dec 8;9:e61920. doi: 10.7554/eLife.61920. Elife. 2020. PMID: 33289484 Free PMC article.
Microarray screening reveals two non-conventional SUMO-binding modules linked to DNA repair by non-homologous end-joining.
Cabello-Lobato MJ, Jenner M, Cisneros-Aguirre M, Brüninghoff K, Sandy Z, da Costa IC, Jowitt TA, Loch CM, Jackson SP, Wu Q, Mootz HD, Stark JM, Cliff MJ, Schmidt CK. Cabello-Lobato MJ, et al. Among authors: cisneros aguirre m. Nucleic Acids Res. 2022 May 6;50(8):4732-4754. doi: 10.1093/nar/gkac237. Nucleic Acids Res. 2022. PMID: 35420136 Free PMC article.
aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, β-arrestin-2-mediated SphK1-S1PR1-Akt signaling axis.
Molinar-Inglis O, Birch CA, Nicholas D, Orduña-Castillo L, Cisneros-Aguirre M, Patwardhan A, Chen B, Grimsey NJ, Coronel LJ, Lin H, Gomez Menzies PK, Lawson MA, Patel HH, Trejo J. Molinar-Inglis O, et al. Among authors: cisneros aguirre m. Proc Natl Acad Sci U S A. 2021 Dec 7;118(49):e2106623118. doi: 10.1073/pnas.2106623118. Proc Natl Acad Sci U S A. 2021. PMID: 34873055 Free PMC article.
Multivalent interactions of the disordered regions of XLF and XRCC4 foster robust cellular NHEJ and drive the formation of ligation-boosting condensates in vitro.
Vu DD, Bonucci A, Brenière M, Cisneros-Aguirre M, Pelupessy P, Wang Z, Carlier L, Bouvignies G, Cortes P, Aggarwal AK, Blackledge M, Gueroui Z, Belle V, Stark JM, Modesti M, Ferrage F. Vu DD, et al. Among authors: cisneros aguirre m. bioRxiv [Preprint]. 2023 Jul 13:2023.07.12.548668. doi: 10.1101/2023.07.12.548668. bioRxiv. 2023. PMID: 37503201 Free PMC article. Preprint.