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A human anti-matriptase-2 antibody limits iron overload, α-globin aggregates, and splenomegaly in β-thalassemic mice.
Wake M, Palin A, Belot A, Berger M, Lorgouilloux M, Bichon M, Papworth J, Bayliss L, Grimshaw B, Rynkiewicz N, Paterson J, Poindron A, Spearing E, Carter E, Hudson R, Campbell M, Petzer V, Besson-Fournier C, Latour C, Largounez A, Gourbeyre O, Fay A, Coppin H, Roth MP, Theurl I, Germaschewski V, Meynard D. Wake M, et al. Among authors: meynard d. Blood Adv. 2024 Apr 23;8(8):1898-1907. doi: 10.1182/bloodadvances.2023012010. Blood Adv. 2024. PMID: 38241484 Free PMC article.
Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice.
Nai A, Rubio A, Campanella A, Gourbeyre O, Artuso I, Bordini J, Gineste A, Latour C, Besson-Fournier C, Lin HY, Coppin H, Roth MP, Camaschella C, Silvestri L, Meynard D. Nai A, et al. Among authors: meynard d. Blood. 2016 May 12;127(19):2327-36. doi: 10.1182/blood-2015-11-681494. Epub 2016 Jan 11. Blood. 2016. PMID: 26755707 Free PMC article.
Regulators of hepcidin expression.
Roth MP, Meynard D, Coppin H. Roth MP, et al. Among authors: meynard d. Vitam Horm. 2019;110:101-129. doi: 10.1016/bs.vh.2019.01.005. Epub 2019 Feb 2. Vitam Horm. 2019. PMID: 30798807 Review.
LJ000328, a novel ALK2/3 kinase inhibitor, represses hepcidin and significantly improves the phenotype of IRIDA.
Belot A, Gourbeyre O, Fay A, Palin A, Besson-Fournier C, Latour C, Hopkins CR, Tidmarsh GF, Coppin H, Roth MP, Ritter MR, Hong CC, Meynard D. Belot A, et al. Among authors: meynard d. Haematologica. 2020 Aug;105(8):e385-e388. doi: 10.3324/haematol.2019.236133. Epub 2019 Dec 5. Haematologica. 2020. PMID: 31806689 Free PMC article. No abstract available.
77 results