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Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation.
Kano Y, Gebregiworgis T, Marshall CB, Radulovich N, Poon BPK, St-Germain J, Cook JD, Valencia-Sama I, Grant BMM, Herrera SG, Miao J, Raught B, Irwin MS, Lee JE, Yeh JJ, Zhang ZY, Tsao MS, Ikura M, Ohh M. Kano Y, et al. Among authors: miao j. Nat Commun. 2019 Jan 15;10(1):224. doi: 10.1038/s41467-018-08115-8. Nat Commun. 2019. PMID: 30644389 Free PMC article.
PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371.
Chen H, Bai Y, Kobayashi M, Xiao S, Cai W, Barajas S, Chen S, Miao J, Meke FN, Vemula S, Ropa JP, Croop JM, Boswell HS, Wan J, Jia Y, Liu H, Li LS, Altman JK, Eklund EA, Ji P, Tong W, Band H, Huang DT, Platanias LC, Zhang ZY, Liu Y. Chen H, et al. Among authors: miao j. Blood. 2023 Jan 19;141(3):244-259. doi: 10.1182/blood.2022016580. Blood. 2023. PMID: 36206490 Free PMC article.
PRL2 Phosphatase Promotes Oncogenic KIT Signaling in Leukemia Cells through Modulating CBL Phosphorylation.
Chen H, Bai Y, Kobayashi M, Xiao S, Barajas S, Cai W, Chen S, Miao J, Nguele Meke F, Yao C, Yang Y, Strube K, Satchivi O, Sun J, Rönnstrand L, Croop JM, Boswell HS, Jia Y, Liu H, Li LS, Altman JK, Eklund EA, Sukhanova M, Ji P, Tong W, Band H, Huang DT, Platanias LC, Zhang ZY, Liu Y. Chen H, et al. Among authors: miao j. Mol Cancer Res. 2024 Jan 2;22(1):94-103. doi: 10.1158/1541-7786.MCR-23-0115. Mol Cancer Res. 2024. PMID: 37756563
Discovery of a SHP2 Degrader with In Vivo Anti-Tumor Activity.
Miao J, Bai Y, Miao Y, Qu Z, Dong J, Zhang RY, Aggarwal D, Jassim BA, Nguyen Q, Zhang ZY. Miao J, et al. Among authors: miao y. Molecules. 2023 Oct 6;28(19):6947. doi: 10.3390/molecules28196947. Molecules. 2023. PMID: 37836790 Free PMC article.
Discovery of a selective TC-PTP degrader for cancer immunotherapy.
Miao J, Dong J, Miao Y, Bai Y, Qu Z, Jassim BA, Huang B, Nguyen Q, Ma Y, Murray AA, Li J, Low PS, Zhang ZY. Miao J, et al. Among authors: miao y. Chem Sci. 2023 Oct 24;14(44):12606-12614. doi: 10.1039/d3sc04541b. eCollection 2023 Nov 15. Chem Sci. 2023. PMID: 38020389 Free PMC article.
3,629 results