Michele Vendruscolo[Author] - Search Results

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Year	Number of Results
2002	6
2003	9
2004	11
2005	16
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2007	17
2008	24
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2010	15
2011	27
2012	19
2013	24
2014	27
2015	33
2016	26
2017	29
2018	30
2019	38
2020	37
2021	42
2022	27
2023	31
2024	8

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Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning.

Horne RI, Andrzejewska EA, Alam P, Brotzakis ZF, Srivastava A, Aubert A, Nowinska M, Gregory RC, Staats R, Possenti A, Chia S, Sormanni P, Ghetti B, Caughey B, Knowles TPJ, Vendruscolo M. Horne RI, et al. Among authors: vendruscolo m. Nat Chem Biol. 2024 Apr 17. doi: 10.1038/s41589-024-01580-x. Online ahead of print. Nat Chem Biol. 2024. PMID: 38632492

RASP: Optimal Single Puncta Detection in Complex Cellular Backgrounds.

Fu B, Brock EE, Andrews R, Breiter JC, Tian R, Toomey CE, Lachica J, Lashley T, Ryten M, Wood NW, Vendruscolo M, Gandhi S, Weiss LE, Beckwith JS, Lee SF. Fu B, et al. Among authors: vendruscolo m. J Phys Chem B. 2024 Apr 18;128(15):3585-3597. doi: 10.1021/acs.jpcb.4c00174. Epub 2024 Apr 9. J Phys Chem B. 2024. PMID: 38593280 Free PMC article.

A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions.

Chia S, Cataldi RL, Ruggeri FS, Limbocker R, Condado-Morales I, Pisani K, Possenti A, Linse S, Knowles TPJ, Habchi J, Mannini B, Vendruscolo M. Chia S, et al. Among authors: vendruscolo m. ACS Chem Neurosci. 2024 Mar 20;15(6):1125-1134. doi: 10.1021/acschemneuro.3c00718. Epub 2024 Feb 28. ACS Chem Neurosci. 2024. PMID: 38416693 Free PMC article.

Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases.

Rinauro DJ, Chiti F, Vendruscolo M, Limbocker R. Rinauro DJ, et al. Among authors: vendruscolo m. Mol Neurodegener. 2024 Feb 20;19(1):20. doi: 10.1186/s13024-023-00651-2. Mol Neurodegener. 2024. PMID: 38378578 Free PMC article. Review.

Modulation of α-synuclein in vitro aggregation kinetics by its alternative splice isoforms.

Röntgen A, Toprakcioglu Z, Tomkins JE, Vendruscolo M. Röntgen A, et al. Among authors: vendruscolo m. Proc Natl Acad Sci U S A. 2024 Feb 13;121(7):e2313465121. doi: 10.1073/pnas.2313465121. Epub 2024 Feb 7. Proc Natl Acad Sci U S A. 2024. PMID: 38324572 Free PMC article.

Maturation-dependent changes in the size, structure and seeding capacity of Aβ42 amyloid fibrils.

Miller A, Chia S, Klimont E, Knowles TPJ, Vendruscolo M, Ruggeri FS. Miller A, et al. Among authors: vendruscolo m. Commun Biol. 2024 Feb 6;7(1):153. doi: 10.1038/s42003-024-05858-7. Commun Biol. 2024. PMID: 38321144 Free PMC article.

Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity.

Horne RI, Wilson-Godber J, González Díaz A, Brotzakis ZF, Seal S, Gregory RC, Possenti A, Chia S, Vendruscolo M. Horne RI, et al. Among authors: vendruscolo m. J Chem Inf Model. 2024 Feb 12;64(3):590-596. doi: 10.1021/acs.jcim.3c01777. Epub 2024 Jan 23. J Chem Inf Model. 2024. PMID: 38261763 Free PMC article.

Bayesian Optimization in the Latent Space of a Variational Autoencoder for the Generation of Selective FLT3 Inhibitors.

Chandra R, Horne RI, Vendruscolo M. Chandra R, et al. Among authors: vendruscolo m. J Chem Theory Comput. 2024 Jan 9;20(1):469-476. doi: 10.1021/acs.jctc.3c01224. Epub 2023 Dec 19. J Chem Theory Comput. 2024. PMID: 38112559 Free PMC article.

Sequence-based prediction of the intrinsic solubility of peptides containing non-natural amino acids.

Oeller M, Kang RJD, Bolt HL, Gomes Dos Santos AL, Weinmann AL, Nikitidis A, Zlatoidsky P, Su W, Czechtizky W, De Maria L, Sormanni P, Vendruscolo M. Oeller M, et al. Among authors: vendruscolo m. Nat Commun. 2023 Nov 17;14(1):7475. doi: 10.1038/s41467-023-42940-w. Nat Commun. 2023. PMID: 37978172 Free PMC article.

Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores.

Sandler SE, Horne RI, Rocchetti S, Novak R, Hsu NS, Castellana Cruz M, Faidon Brotzakis Z, Gregory RC, Chia S, Bernardes GJL, Keyser UF, Vendruscolo M. Sandler SE, et al. Among authors: vendruscolo m. J Am Chem Soc. 2023 Nov 29;145(47):25776-25788. doi: 10.1021/jacs.3c09335. Epub 2023 Nov 16. J Am Chem Soc. 2023. PMID: 37972287 Free PMC article.

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