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RIP1 activates PI3K-Akt via a dual mechanism involving NF-kappaB-mediated inhibition of the mTOR-S6K-IRS1 negative feedback loop and down-regulation of PTEN.
Park S, Zhao D, Hatanpaa KJ, Mickey BE, Saha D, Boothman DA, Story MD, Wong ET, Burma S, Georgescu MM, Rangnekar VM, Chauncey SS, Habib AA. Park S, et al. Among authors: mickey be. Cancer Res. 2009 May 15;69(10):4107-11. doi: 10.1158/0008-5472.CAN-09-0474. Epub 2009 May 12. Cancer Res. 2009. PMID: 19435890 Free PMC article.
An EGFR wild type-EGFRvIII-HB-EGF feed-forward loop regulates the activation of EGFRvIII.
Li L, Chakraborty S, Yang CR, Hatanpaa KJ, Cipher DJ, Puliyappadamba VT, Rehman A, Jiwani AJ, Mickey B, Madden C, Raisanen J, Burma S, Saha D, Wang Z, Pingle SC, Kesari S, Boothman DA, Habib AA. Li L, et al. Oncogene. 2014 Aug 14;33(33):4253-64. doi: 10.1038/onc.2013.400. Epub 2013 Sep 30. Oncogene. 2014. PMID: 24077285 Free PMC article.
High expression of the stem cell marker nestin is an adverse prognostic factor in WHO grade II-III astrocytomas and oligoastrocytomas.
Hatanpaa KJ, Hu T, Vemireddy V, Foong C, Raisanen JM, Oliver D, Hiemenz MC, Burns DK, White CL 3rd, Whitworth LA, Mickey B, Stegner M, Habib AA, Fink K, Maher EA, Bachoo RM. Hatanpaa KJ, et al. J Neurooncol. 2014 Mar;117(1):183-189. doi: 10.1007/s11060-014-1376-7. Epub 2014 Feb 12. J Neurooncol. 2014. PMID: 24519516 Free PMC article.
118 results