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Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD.
Gupta U, Ghosh S, Wallace CT, Shang P, Xin Y, Nair AP, Yazdankhah M, Strizhakova A, Ross MA, Liu H, Hose S, Stepicheva NA, Chowdhury O, Nemani M, Maddipatla V, Grebe R, Das M, Lathrop KL, Sahel JA, Zigler JS Jr, Qian J, Ghosh A, Sergeev Y, Handa JT, St Croix CM, Sinha D. Gupta U, et al. Among authors: nemani m. Autophagy. 2023 Jan;19(1):92-111. doi: 10.1080/15548627.2022.2062887. Epub 2022 Apr 26. Autophagy. 2023. PMID: 35473441 Free PMC article.
The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in atrophic AMD.
Ghosh S, Sharma R, Bammidi S, Koontz V, Nemani M, Yazdankhah M, Kedziora KM, Wallace CT, Yu-Wei C, Franks J, Bose D, Rajasundaram D, Hose S, Sahel JA, Puertollano R, Finkel T, Zigler JS, Sergeev Y, Watkins SC, Goetzman ES, Flores-Bellver M, Kaarniranta K, Sodhi A, Bharti K, Handa JT, Sinha D. Ghosh S, et al. Among authors: nemani m. bioRxiv [Preprint]. 2023 Aug 9:2023.08.08.552343. doi: 10.1101/2023.08.08.552343. bioRxiv. 2023. PMID: 37609254 Free PMC article. Preprint.
Microglia-Neutrophil Interactions Drive Dry AMD-like Pathology in a Mouse Model.
Boyce M, Xin Y, Chowdhury O, Shang P, Liu H, Koontz V, Strizhakova A, Nemani M, Hose S, Zigler JS Jr, Campbell M, Sinha D, Handa JT, Kaarniranta K, Qian J, Ghosh S. Boyce M, et al. Among authors: nemani m. Cells. 2022 Nov 9;11(22):3535. doi: 10.3390/cells11223535. Cells. 2022. PMID: 36428965 Free PMC article.