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Bcl-2 and IP3 compete for the ligand-binding domain of IP3Rs modulating Ca2+ signaling output.
Ivanova H, Wagner LE 2nd, Tanimura A, Vandermarliere E, Luyten T, Welkenhuyzen K, Alzayady KJ, Wang L, Hamada K, Mikoshiba K, De Smedt H, Martens L, Yule DI, Parys JB, Bultynck G. Ivanova H, et al. Among authors: mikoshiba k. Cell Mol Life Sci. 2019 Oct;76(19):3843-3859. doi: 10.1007/s00018-019-03091-8. Epub 2019 Apr 16. Cell Mol Life Sci. 2019. PMID: 30989245
Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis.
Rosa N, Ivanova H, Wagner LE 2nd, Kale J, La Rovere R, Welkenhuyzen K, Louros N, Karamanou S, Shabardina V, Lemmens I, Vandermarliere E, Hamada K, Ando H, Rousseau F, Schymkowitz J, Tavernier J, Mikoshiba K, Economou A, Andrews DW, Parys JB, Yule DI, Bultynck G. Rosa N, et al. Among authors: mikoshiba k. Cell Death Differ. 2022 Apr;29(4):788-805. doi: 10.1038/s41418-021-00894-w. Epub 2021 Nov 8. Cell Death Differ. 2022. PMID: 34750538 Free PMC article.
808 results