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Initial experience in the treatment of inherited mitochondrial disease with EPI-743.
Enns GM, Kinsman SL, Perlman SL, Spicer KM, Abdenur JE, Cohen BH, Amagata A, Barnes A, Kheifets V, Shrader WD, Thoolen M, Blankenberg F, Miller G. Enns GM, et al. Among authors: miller g. Mol Genet Metab. 2012 Jan;105(1):91-102. doi: 10.1016/j.ymgme.2011.10.009. Epub 2011 Oct 21. Mol Genet Metab. 2012. PMID: 22115768 Free article. Clinical Trial.
EPI-743 reverses the progression of the pediatric mitochondrial disease--genetically defined Leigh Syndrome.
Martinelli D, Catteruccia M, Piemonte F, Pastore A, Tozzi G, Dionisi-Vici C, Pontrelli G, Corsetti T, Livadiotti S, Kheifets V, Hinman A, Shrader WD, Thoolen M, Klein MB, Bertini E, Miller G. Martinelli D, et al. Among authors: miller g. Mol Genet Metab. 2012 Nov;107(3):383-8. doi: 10.1016/j.ymgme.2012.09.007. Epub 2012 Sep 10. Mol Genet Metab. 2012. PMID: 23010433 Clinical Trial.
α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging.
Shrader WD, Amagata A, Barnes A, Enns GM, Hinman A, Jankowski O, Kheifets V, Komatsuzaki R, Lee E, Mollard P, Murase K, Sadun AA, Thoolen M, Wesson K, Miller G. Shrader WD, et al. Among authors: miller g. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3693-8. doi: 10.1016/j.bmcl.2011.04.085. Epub 2011 Apr 24. Bioorg Med Chem Lett. 2011. PMID: 21600768
Towards a modern definition of vitamin E-evidence for a quinone hypothesis.
Shrader WD, Amagata A, Barnes A, Hinman A, Jankowski O, Lee E, Kheifets V, Komatsuzaki R, Mollard P, Murase K, Rioux P, Wesson K, Miller G. Shrader WD, et al. Among authors: miller g. Bioorg Med Chem Lett. 2012 Jan 1;22(1):391-5. doi: 10.1016/j.bmcl.2011.10.117. Epub 2011 Nov 15. Bioorg Med Chem Lett. 2012. PMID: 22137789
Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase.
Hinman A, Holst CR, Latham JC, Bruegger JJ, Ulas G, McCusker KP, Amagata A, Davis D, Hoff KG, Kahn-Kirby AH, Kim V, Kosaka Y, Lee E, Malone SA, Mei JJ, Richards SJ, Rivera V, Miller G, Trimmer JK, Shrader WD. Hinman A, et al. Among authors: miller g. PLoS One. 2018 Aug 15;13(8):e0201369. doi: 10.1371/journal.pone.0201369. eCollection 2018. PLoS One. 2018. PMID: 30110365 Free PMC article.
Japanese Leigh syndrome case treated with EPI-743.
Kouga T, Takagi M, Miyauchi A, Shimbo H, Iai M, Yamashita S, Murayama K, Klein MB, Miller G, Goto T, Osaka H. Kouga T, et al. Among authors: miller g. Brain Dev. 2018 Feb;40(2):145-149. doi: 10.1016/j.braindev.2017.08.005. Epub 2017 Sep 12. Brain Dev. 2018. PMID: 28916229
6,052 results