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A kinase-cGAS cascade to synthesize a therapeutic STING activator.
McIntosh JA, Liu Z, Andresen BM, Marzijarani NS, Moore JC, Marshall NM, Borra-Garske M, Obligacion JV, Fier PS, Peng F, Forstater JH, Winston MS, An C, Chang W, Lim J, Huffman MA, Miller SP, Tsay FR, Altman MD, Lesburg CA, Steinhuebel D, Trotter BW, Cumming JN, Northrup A, Bu X, Mann BF, Biba M, Hiraga K, Murphy GS, Kolev JN, Makarewicz A, Pan W, Farasat I, Bade RS, Stone K, Duan D, Alvizo O, Adpressa D, Guetschow E, Hoyt E, Regalado EL, Castro S, Rivera N, Smith JP, Wang F, Crespo A, Verma D, Axnanda S, Dance ZEX, Devine PN, Tschaen D, Canada KA, Bulger PG, Sherry BD, Truppo MD, Ruck RT, Campeau LC, Bennett DJ, Humphrey GR, Campos KR, Maddess ML. McIntosh JA, et al. Among authors: miller sp. Nature. 2022 Mar;603(7901):439-444. doi: 10.1038/s41586-022-04422-9. Epub 2022 Mar 16. Nature. 2022. PMID: 35296845
Diverse Catalytic Reactions for the Stereoselective Synthesis of Cyclic Dinucleotide MK-1454.
Benkovics T, Peng F, Phillips EM, An C, Bade RS, Chung CK, Dance ZEX, Fier PS, Forstater JH, Liu Z, Liu Z, Maligres PE, Marshall NM, Salehi Marzijarani N, McIntosh JA, Miller SP, Moore JC, Neel AJ, Obligacion JV, Pan W, Pirnot MT, Poirier M, Reibarkh M, Sherry BD, Song ZJ, Tan L, Turnbull BWH, Verma D, Waldman JH, Wang L, Wang T, Winston MS, Xu F. Benkovics T, et al. Among authors: miller sp. J Am Chem Soc. 2022 Apr 6;144(13):5855-5863. doi: 10.1021/jacs.1c12106. Epub 2022 Mar 25. J Am Chem Soc. 2022. PMID: 35333525
Synthesis of the γ-Secretase Modulator MK-8428.
Miller SP, Morris WJ, Orr RK, Eckert J, Milan J, Maust M, Cowden C, Cui J. Miller SP, et al. J Org Chem. 2017 Mar 17;82(6):2957-2964. doi: 10.1021/acs.joc.6b02979. Epub 2017 Mar 6. J Org Chem. 2017. PMID: 28262021
Fetal Hemodynamics, Early Survival, and Neurodevelopment in Patients With Cyanotic Congenital Heart Disease.
Lee FT, Sun L, van Amerom JFP, Portnoy S, Marini D, Saini A, Milligan N, Lim JM, Saini B, Selvanathan T, Kazazian V, Sananes R, Jaeggi E, Kingdom JC, Macgowan CK, Ly L, Chau V, Miller SP, Seed M. Lee FT, et al. Among authors: miller sp. J Am Coll Cardiol. 2024 Apr 2;83(13):1225-1239. doi: 10.1016/j.jacc.2024.02.005. Epub 2024 Mar 25. J Am Coll Cardiol. 2024. PMID: 38538202 Free article.
Transient Receptor Potential Melastatin 7 (TRPM7) Ion Channel Inhibitors: Preliminary SAR and Conformational Studies of Xenicane Diterpenoids from the Hawaiian Soft Coral Sarcothelia edmondsoni.
Yao G, Parris MR, Kuo WC, Pörzgen P, Castillo B, Mason ES, Chinchilla A, Huang J, Suzuki S, Ross R, Akana E, Vander Schuit S, Miller SP, Penner R, Sun HS, Feng ZP, Hull KG, Romo D, Fleig A, Horgen FD. Yao G, et al. Among authors: miller sp. J Nat Prod. 2024 Apr 26;87(4):783-797. doi: 10.1021/acs.jnatprod.3c00942. Epub 2024 Mar 27. J Nat Prod. 2024. PMID: 38537009
456 results